Granular cells in odontogenic and non-odontogenic tumours

Rühl, G. H.; Akuamoa-Boateng, E

doi:10.1007/bf00747741

Cited by 26 publications

(25 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Granular cells can be seen in various oral lesions, such as granular cell ameloblastoma, granular cell ameloblastic fibroma, granular cell tumor and congenital epulis (3,(9)(10)(11). Although these lesions are similar morphologically, their origin differs (4,(7)(8)(9)(10)(11).…”

Section: Cellular Characterizationmentioning

confidence: 99%

See 1 more Smart Citation

Immunohistochemical and ultrastructural investigation of apoptotic cell death in granular cell ameloblastoma

Kumamoto

Ooya

2001

J Oral Pathology Medicine

View full text Add to dashboard Cite

Apoptotic cell death in granular cell ameloblastomas was examined by immunohistochemistry using anti-single-stranded DNA (ssDNA) antibody and transmission electron microscopy. Routinely prepared sections of granular cell ameloblastomas showed various quantities of granular cells with some apoptotic nuclear fragments. Immunoreactivity for ssDNA was higher in granular cells than in other neoplastic cells. Ultrastructural examination revealed abundant lysosomes in the cytoplasm of granular cells. Numerous apoptotic cell fragments with condensed nuclei in granular cell clusters were phagocytosed by adjacent granular cells. On immunohistochemical characterization of cellular differentiation, granular cells were positive for cytokeratin, CD68, lysozyme and alpha-1-antichymotrypsin, but negative for vimentin, desmin, S-100 protein, neuron-specific enolase and CD15, indicating epithelial origin and lysosomal aggregation. These features suggest that the cytoplasmic granularity in granular cell ameloblastomas might be caused by increased apoptotic cell death of neoplastic cells and associated phagocytosis by neighboring neoplastic cells.

show abstract

Section: Cellular Characterizationmentioning

confidence: 99%

“…Granular cell ameloblastoma is an unusual variant of ameloblastoma that shows granular transformation of neoplastic cells (1)(2)(3)(4). Ultrastructural (5-7), histochemical (7,8) and immunohistochemical (4,(9)(10)(11) studies have revealed that cytoplasmic granularity is caused by lysosomal overload; however, the mechanism involved remains poorly understood.…”

mentioning

confidence: 99%

Immunohistochemical and ultrastructural investigation of apoptotic cell death in granular cell ameloblastoma

Kumamoto

Ooya

2001

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…Radiographically, it invariably presents as a unilocular or multilocular radiolucency, although a radiopaque presentation has been described. The case described in this report was consistent with these features, presenting as a discrete unilocular radiolucency.…”

Section: Discussionmentioning

confidence: 99%

A granular‐cell odontogenic tumour occurring alongside orofacial granulomatosis: a report of the first case

et al. 2014

View full text Add to dashboard Cite

This article describes a case of a granular-cell odontogenic tumour occurring in the mandible of a 19-year-old woman alongside a presentation of orofacial granulomatosis. The granular-cell odontogenic tumour is an extremely rare lesion, with fewer than 40 documented cases, and orofacial granulomatosis is itself an uncommon condition. The simultaneous occurrence of the two lesions has not previously been described. bs_bs_banner Oral Surgery ISSN 1752-2471 42 Oral Surgery 8 (2015) 42-47.

show abstract

“…One such classification on oral granular cell lesions including odontogenic and nonodontogenic tumors was proposed, but has not included many granular cell lesions [5]. Hence we made an attempt to classify granular cell lesions as below.…”

Section: Classificationmentioning

confidence: 99%

Granules in Granular Cell Lesions of the Head and Neck: A Review

Yogesh

Sowmya

2011

ISRN Pathology

View full text Add to dashboard Cite

Granular cell lesions of the oral mucosa, jaws, and salivary glands constitute a heterogeneous group of lesions which may be either odontogenic, salivary gland, or metastatic in origin. Granular cells in these proliferations most commonly are the result of lysosomal accumulation, aging, degenerative, metabolic alteration, increased apoptosis, cytoplasmic autophagocytosis, and many more. Many benign and malignant tumors that occur in the oral cavity contain granular cells as a characteristic component of their pathology. Sometimes dilemma exists in the proper diagnosis of these granular cell lesions and the cell of origin because they share similar light and electron microscopic features. Therefore, immunohistochemistry helps to confirm histologic impressions and differentiate other neoplastic entities with granular cytoplasmic features. Granularity in a normal histopathology is a rare but innocuous change and does not influence the biologic behaviour of smooth muscle tumors except few lesions such as cutaneous granular cell angiosarcoma and granular cell ameloblastoma which have shown poor prognosis. This paper aims to review the clinical and pathologic features, different immunohistochemical profiles of granules in granular cell lesions of head and neck with an attempted working classification.

show abstract

Granular cells in odontogenic and non-odontogenic tumours

Cited by 26 publications

References 31 publications

Immunohistochemical and ultrastructural investigation of apoptotic cell death in granular cell ameloblastoma

Immunohistochemical and ultrastructural investigation of apoptotic cell death in granular cell ameloblastoma

A granular‐cell odontogenic tumour occurring alongside orofacial granulomatosis: a report of the first case

Granules in Granular Cell Lesions of the Head and Neck: A Review

Contact Info

Product

Resources

About