Granular juxtaglomerular cells and prorenin synthesis in mice treated with enalapril

Berka, Jennifer L.; Alcorn, Daine; Coghlan, John P.; Fernley, Ross T.; Morgan, Trefor; Ryan, Graeme B.; Skinner, Sandford L.; Weaver, Debbi

doi:10.1097/00004872-199003000-00004

Cited by 28 publications

(23 citation statements)

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“…After 14 days of enalapril treatment, Berka et al (1990) found that the volume of extraglomerular region with renin-containing cells expressed as a fraction of the glomerular volume increased threefold. These increases are difficult to compare because the present volumes are totals whereas the volumes reported by Berka et al are relative and, moreover, they are volumes of a different structure in the kidney.…”

Section: Discussionmentioning

confidence: 98%

Quantitative changes in rat renin secretory granules after acute and chronic stimulation of the renin system

Rasch

Jensen

Nyengaard

et al. 1998

Cell and Tissue Research

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In order to study the cellular mode of renin secretion, stereological methods were used to estimate number and volume of rat renin secretory granules during stimulation of the renin system. An acute decrease in renal perfusion pressure to 40 mmHg for 5 min increased plasma renin concentration (PRC) twofold, but did not significantly change the number of renin granules per arteriole or the renin-containing volume of the arteriole. Chronic stimulation was achieved by a combination of low-salt diet and inhibition of angiotensin-converting enzyme (ACE) for 14 days, and resulted in a 36-fold increase in PRC, a 20-fold increase in the number of granules per arteriole, and a 17-fold increase in the arteriolar volume that contained renin. An acute decrease in renal perfusion pressure to 40 mmHg for 5 min in the chronically stimulated rats increased PRC further (1.6-fold), and significantly reduced the number of granules per arteriole by 4000 (45% reduction), but did not change the renin-containing arteriolar volume significantly. The average renin granule size was 0.35 microm3 with no significant differences among the groups. We conclude that recruited granular cells contribute significantly to renin release, and that all granular cells along the arteriole participate in secretory responses. The reduced number of renin granules after acute stimulation is compatible with exocytosis as the dominating mechanism of renin release.

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Section: Discussionmentioning

confidence: 98%

Quantitative changes in rat renin secretory granules after acute and chronic stimulation of the renin system

Rasch

Jensen

Nyengaard

et al. 1998

Cell and Tissue Research

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“…[1][2][3][4][5] We have reported that Zucker fatty rats (ZFRs) presented with unusual proliferative changes of smooth muscle cells (SMCs) in afferent arteriolar walls and an extreme increase in renin-producing cells following long-term oral administration of ARB. 6 ARBs are widely used in adult patients with hypertension and kidney diseases.…”

Section: Introductionmentioning

confidence: 99%

Proliferative changes of renal arteriolar walls induced by administration of angiotensin II receptor blocker are frequent in juvenile rats

Nagai

Nakanishi

Akimoto

et al. 2013

J Renin Angiotensin Aldosterone Syst

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Introduction: Our previous study of angiotensin II receptor blocker (ARB) administration in rats induced unusual proliferative changes of smooth muscle cells in renal arteriolar walls. The present study examined if the incidence of the changes depended on the rats' age, and how long it would take to find changes. Materials and methods: Six-week-old (juvenile spontaneous hypertensive rats (SHRs)+ARB group, n=15) and 20-week-old (adult SHRs+ARB group, n=10) male SHRs were fed a standard diet (0.4% NaCl) containing valsartan (10 mg/kg/day; Novartis Co.). Fifteen age-matched SHRs were studied as controls. After 4, 8, and 12 weeks, the rat kidneys were examined under light and electron microscopes and through immunohistochemical studies. Results: Extremely concentric proliferative changes in afferent arteriolar walls were frequently observed in the juvenile SHR+ARB group compared to the adult SHR+ARB group (48.7±6.8% vs 19.3±6.9%; p=0.0307) at the 12 th week. Increased renin expression and arteriolar changes were found from the 4 th week in the juvenile SHR+ARB group. Conclusion: This study indicates that ARB administration induces unusual proliferative changes and a marked reninproducing cell increase in afferent arterioles more frequently in juveniles than adult rats. It is suggested that the treatment of ARB in juveniles might have a higher risk of changes in renal afferent arterioles.

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“…An attractive model to explain hypertrophy and hyperplasia ofthe JGA in states associated with increased renin production suggests that angiotensin II stimulates renal TGF-# expression and that TGF-# acts in a paracrine or autocrine fashion to promote cellular hypertrophy. On the other hand, angiotensinconverting enzyme inhibition is also associated with hypertrophy and hyperplasia of the JGA (25). This would suggest that renin itself, rather than angiotensin II, might stimulate TGF-#2 synthesis.…”

Section: Methodsmentioning

confidence: 99%

Water deprivation stimulates transforming growth factor-beta 2 accumulation in the juxtaglomerular apparatus of mouse kidney.

Horikoshi¹,

McCune²,

Ray³

et al. 1991

J. Clin. Invest.

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Granular juxtaglomerular cells and prorenin synthesis in mice treated with enalapril

Cited by 28 publications

References 0 publications

Quantitative changes in rat renin secretory granules after acute and chronic stimulation of the renin system

Quantitative changes in rat renin secretory granules after acute and chronic stimulation of the renin system

Proliferative changes of renal arteriolar walls induced by administration of angiotensin II receptor blocker are frequent in juvenile rats

Water deprivation stimulates transforming growth factor-beta 2 accumulation in the juxtaglomerular apparatus of mouse kidney.

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