2016
DOI: 10.1016/j.ejpb.2016.05.011
|View full text |Cite
|
Sign up to set email alerts
|

Granule size distributions after twin-screw granulation – Do not forget the feeding systems

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
19
0

Year Published

2017
2017
2023
2023

Publication Types

Select...
6

Relationship

0
6

Authors

Journals

citations
Cited by 44 publications
(19 citation statements)
references
References 44 publications
0
19
0
Order By: Relevance
“…The screw diameter was 16 mm and the length (L) of the screws was 41 times the diameter (D). The screw consisted of conveying elements to transport the powder and the granules with minimum shear stress, kneading elements to promote a mixing of powder and liquid and to densify granules and distributive flow elements, to narrow the granule sizes [6,14,15]. The screw was configured as follows: 1 kneading disc ( Powder was fed with a loss-in-weight twin-screw feeder (K-ML-KT 20, K-Tron, Switzerland) into the first zone of the extruder at a set feed-rate of 20 g min -1 .…”
Section: Twin-screw Granulationmentioning
confidence: 99%
“…The screw diameter was 16 mm and the length (L) of the screws was 41 times the diameter (D). The screw consisted of conveying elements to transport the powder and the granules with minimum shear stress, kneading elements to promote a mixing of powder and liquid and to densify granules and distributive flow elements, to narrow the granule sizes [6,14,15]. The screw was configured as follows: 1 kneading disc ( Powder was fed with a loss-in-weight twin-screw feeder (K-ML-KT 20, K-Tron, Switzerland) into the first zone of the extruder at a set feed-rate of 20 g min -1 .…”
Section: Twin-screw Granulationmentioning
confidence: 99%
“…For further details of the pump, the reader is referred to previously published studies. 4,14 Liquid feed rate was monitored by a Coriolis mass flow measurement system (Proline Promass 80A; EndressþHauser, Weil am Rhein, Germany). The applied liquid to solid ratios (L/S) are specified in Table 1.…”
Section: Twin Screw Granulationmentioning
confidence: 99%
“…[1][2][3][4][5][6][7] Most of the studies examined process analytical tools for TSG or the influence of process parameters on critical quality attributes (CQAs) of granules or subsequently produced tablets. [8][9][10][11][12][13][14] In these studies, the pharmaceutical formulations were often kept constant, resulting in little data on formulation dependencies of the process. Some studies dealt with formulation changes at constant process parameters and used different batches, polymorphs, or qualities of the same substance, [15][16][17][18] or varied the hydrophobicity of the formulation by the mass ratio of the applied excipients.…”
Section: Introductionmentioning
confidence: 99%
“…3,4 However, in reality the appearance of changes in raw material properties, equipment status with respect to physical wear and varying ambient conditions contribute to disturbances which vary in time and demand for continuous corrective actions during production. 7 Recent studies in the field of continuous drug product manufacturing have therefore investigated the potential to continuously detect undesired powder feed rate deviations and their accompanied disturbances in product uniformity at an early stage using process understanding and advanced monitoring tools. The traditional manufacturing approach which generally adopts automatic regulatory process control in combination with manual supervision, does not compensate in real-time for such critical quality attribute (CQA) variations.…”
Section: Introductionmentioning
confidence: 99%
“…Not only is this necessary to ensure the final drug potency despite process disturbances, but also to ensure the physical characteristics of the intermediate product. 7 Recent studies in the field of continuous drug product manufacturing have therefore investigated the potential to continuously detect undesired powder feed rate deviations and their accompanied disturbances in product uniformity at an early stage using process understanding and advanced monitoring tools. [8][9][10][11] The next step is to use the acquired knowledge and monitoring tools to control the continuous feeding of the raw materials.…”
Section: Introductionmentioning
confidence: 99%