Granulocytapheresis in steroid-dependent and steroid-resistant patients with inflammatory bowel disease: A prospective observational study

Abstract

GCAP therapy is safe and effective in inducing and maintaining clinical remission both in SD and in SR patients affected by either UC or CD.

Efficacy of cytapheresis for remission induction and dermatological manifestations of ulcerative colitis

“…In this study, the efficacy of cytapheresis was retrospectively evaluated in a large number of consecutive patients treated at our university hospital over several years. We found an efficacy rate of about 70%, close to the level, and in line with efficacy outcomes reported in this clinical setting . Further, considering cytapheresis in IBD patients as a nondrug treatment intervention, selectivity is essential because although patients have activated and often elevated myeloid lineage leucocytes (granulocytes and monocytes), lymphocytes are compromised, and should be spared .…”

“…We found an efficacy rate of about 70%, close to the level, and in line with efficacy outcomes reported in this clinical setting . Further, considering cytapheresis in IBD patients as a nondrug treatment intervention, selectivity is essential because although patients have activated and often elevated myeloid lineage leucocytes (granulocytes and monocytes), lymphocytes are compromised, and should be spared . In fact, an elevated granulocyte/lymphocyte ratio has been found to predict clinical relapse in UC setting .…”

Efficacy and safety of granulocyte adsorption apheresis in elderly patients with ulcerative colitis

“…In the present patient series, CAP was performed in patients with moderate or severe UC that required hospitalization, and a high remission rate was achieved. In general, CAP has the advantage of causing only mild adverse effects . There were few adverse effects of CAP in either the present study's younger group or the elderly group, and all events were reversible.…”

Tacrolimus for remission induction in ulcerative colitis: Mayo endoscopic subscore 0 and 1 predict long-term prognosis

“…With this background in mind, granulocyte and monocyte apheresis (GMA) with an Adacolumn is widely used in Japan as a non-pharmacologic treatment intervention [24]. First episode cases as well as drug steroid naïve patients respond well and attain a good future clinical course by avoiding steroids at an early stage of UC [24][25][26][27][28][29].…”