Granulocyte Antigens and Antibodies

“…This conclusion is supported by the finding that the NB2‐bearing glycoprotein has a smaller molecular weight of 46–56 kDa ( Wu et al ., 1993 ). Furthermore, NB2 has a serological reactivity identical to 9a (human monocyte antigen, HMA‐1) but the gene frequencies for HNA‐2a and 9a are inconsistent with simple allelism between these antigens ( Lalezari et al ., 1982 ; McCullough et al ., 1987 ).…”

Section: Polymorphisms Resulting In Granulocyte Alloantigensmentioning

confidence: 99%

Platelet and granulocyte glycoprotein polymorphisms

Lucas¹,

Metcalfe

2000

Transfusion Medicine

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“…If the initial screen was positive, further identification of specific antibodies was done by monoclonal antibody immobilization of granulocyte antigens. Maternal sera were also screened for the presence of antibody reacting to human leukocyte antigens by a lymphocytotoxic assay (19).…”

Section: Methodsmentioning

confidence: 99%

"Idiopathic neutropenia" in very low birthweight infants

Juul

Calhoun

Christensen

1998

SPAE

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We employed a standardized investigative approach to evaluate four cases of "idiopathic neutropenia" in very low birthweight infants. The evaluation included maternal anti-neutrophil antibodies, a marrow aspiration, and a three-day trial of recombinant granulocyte colony-stimulating factor (rG-CSF). All patients had neutropenia at or shortly following delivery, and remained neutropenic (generally <500/microl) for 1-9 weeks until rG-CSF was administered. Blood and bone marrow studies in all 4 indicated that the neutropenia was: (i) the kinetic result of diminished neutrophil production; (ii) not alloimmune; (iii) not cyclic; and (iv) not associated with recognized inborn errors, bacterial or viral infections, or medications. All responded to rG-CSF by transiently increasing their blood neutrophils to normal, and the neutropenia resolved in all cases with time. It is likely that "idiopathic neutropenia" in this population represents a common phenotype of several different causes, rather than a single entity. Some cases, perhaps the majority, will respond to a short course of rG-CSF administration.

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Granulocyte Antigens and Antibodies

Cited by 22 publications

References 60 publications

Human neutrophil alloantigens

Human neutrophil alloantigens

Platelet and granulocyte glycoprotein polymorphisms

"Idiopathic neutropenia" in very low birthweight infants

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