Granulocyte colony-stimulating factor and platelet aggregation

Effect of Granulocyte Colony-Stimulating Factor Treatment at a Low Dose but for a Long Duration in Patients With Coronary Heart Disease

“…It has been reported that G-CSF facilitates platelet aggregation, 17,18 and the injection of 10 g/kg per day filgrastim for 4 or 5 days in patients with angina pectoris and AMI induced serious complications of restenosis after PCI and acute coronary syndrome. 8,9 Similar life-threatening complications by G-CSF injection, including myocardial and cerebral infarction and spontaneous rupture of the spleen, have already been reported in peripheral blood stem cell transplantation in healthy humans.…”

Timely Withdrawal of G-CSF Reduces the Occurrence of Thrombocytopenia During Dose-dense Chemotherapy

“…This means that after a 2 days G-CSF-free interval compared to a 5 days interval more progenitor cells are still proliferating and this might explain in part the observed impact of G-CSF schedule on myelotoxicity. A functional G-CSF receptor on PLT's has been identified [18] and there is some in vivo evidence that G-CSF has a suppressive effect on the maturation of mouse bone marrow megakaryocytes when monitored by the DNA polyploidy [19]. When G-CSF is given to healthy donors a drop in PLT count is seen by day 8 and an even lower than pre-treatment PLT level by day 10 [20,21].…”

A prospective study of G-CSF effects on hemostasis in allogeneic blood stem cell donors

“…However, the timing of testing might be important since it has been demonstrated that platelet aggregation increases when tested soon after G-CSF (within 18 h), [3][4][5][6] while no change is seen when it is tested at 48 and 96 h. 7 In our study, platelet aggregation was tested slightly more than 96 h after G-CSF, and we demonstrate a decrease in platelet aggregation that was very consistent in all patients but one. A phenomenon of 'platelet exhaustion' was reported after strenuous exercise of long duration, 23 during hemolytic-uremic syndrome, 24 and during pre-eclampsia.…”

“…Shimoda and others have shown that G-CSF receptors are present on the surface of platelets. 2,3 These receptors appear to be functional in vitro 2 and in vivo 4,5 in healthy volunteers. However, the consequences on hemostasis of these findings are conflicting.…”

“…Other investigators have also observed an increase in platelet aggregation, in platelet activation, in von Willebrand factor and in thrombin-antithrombin complex after G-CSF, but these results could not be confirmed. 2,[4][5][6][7][8][9][10] To date, two cases of thrombosis occurring in normal donors have been reported. 11 The first one was a healthy 54-year-old woman who developed a cerebrovascular accident 2 days after completing an uneventful stem cell donation.…”