2012
DOI: 10.4103/2249-4847.105993
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Granulocyte colony-stimulating factor for preterms with sepsis and neutropenia: A randomized controlled trial

Abstract: Background:Bacterial sepsis is one of the major causes of mortality in newborn infants. Mortality increases when sepsis is associated with neutropenia.Materials and Methods:We conducted a prospective, randomized, double-blind, placebo-controlled trial of recombinant human granulocyte colony-stimulating factor on preterm neonates (gestational age (GA) <34 weeks) with sepsis and absolute neutrophil count (ANC) of <1500 cells/mm3. Mortality, duration of Neonatal Intensive Care Unit (NICU) stay, hematological para… Show more

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Cited by 22 publications
(23 citation statements)
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“…One should keep in mind that resistance to G-CSF in NAIN associated with anti-HNA-2 antibodies, possibly due to a G-CSF-induced increase of HNA-2 expression on the neutrophils, has been described [63,64,65]. Despite the stimulated production of neutrophils, controversial results on the benefit of G-CSF in terms of infection-free survival have been published [66,67,68,69,70]. …”
Section: Treatmentmentioning
confidence: 99%
“…One should keep in mind that resistance to G-CSF in NAIN associated with anti-HNA-2 antibodies, possibly due to a G-CSF-induced increase of HNA-2 expression on the neutrophils, has been described [63,64,65]. Despite the stimulated production of neutrophils, controversial results on the benefit of G-CSF in terms of infection-free survival have been published [66,67,68,69,70]. …”
Section: Treatmentmentioning
confidence: 99%
“…The positive contribution of rhG-CSF to neonatal sepsis as well as neutropenia has been studied in various studies (30,(38)(39)(40). In this study, it was indicated that rhG-CSF was associated with considerable improvements in the number of WBC and ANC, while no significant changes were observed in the serum level of hs-CRP and immature/total neutrophil ratio.…”
Section: Discussionmentioning
confidence: 83%
“…Length of NICU stay was reduced significantly in the G-CSF group, as well. In their study, G-CSF was administered intravenously in a single daily dose of 10 µg/kg/day in a 5% dextrose solution over 20 -40 minutes for three consecutive days (30). Although Schibler et al did not observe a substantial difference in ANC between the treated (10 µg/kg/d for 3 days) and control groups with neutropenia (ANC: G-CSF group 1698 ± 2167 cells/µL, placebo group 1249 ± 877 cells/µL) and EONS, other findings such as morbidity, mortality, and immature to total neutrophil ratio were significantly different (43).…”
Section: Discussionmentioning
confidence: 99%
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“…A multicentre randomized trial in France in preterm infants with neutropenia (ANC <1·5 × 10 9 /l) demonstrated that G‐CSF neutrophil counts increased but did not show a benefit in terms of infection‐free survival (Kuhn et al , ). A randomized controlled trial in Kolkata, India of premature infants with gestational age less than 32 weeks and blood neutrophil counts less than 1·5 × 10 9 /l, however, showed that administration of G‐CSF resulted in significantly improved survival (Chaudhuri et al , ). Based on a large experience in managing neonates in intensive care, Christensen () recommended treating neonates with severe neutropenia (ANC < 0·5 × 10 9 /l) that last for 2 days or more with G‐CSF when the cause of severe neutropenia is uncertain.…”
Section: Neutropenia In Premature Infantsmentioning
confidence: 99%