Granulocyte colony-stimulating factor (G-CSF) receptor gene expression of ovarian carcinoma does not correlate with G-CSF caused cell proliferation

Brandstëtter, Thomas; Ninci, Elena; Bettendorf, Herta; Perewusnyk, Gloria; Stolte, Jens; Herchenbach, Dieter; Sellin, D.; Wagner, Edgar; Köchli, Ossi R.; Bauknecht, Thomas

doi:10.1002/1097-0142(20010401)91:7<1372::aid-cncr1141>3.0.co;2-e

Cited by 12 publications

(13 citation statements)

References 51 publications

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“…Although the major action of rhG-CSF is to promote granulocyte proliferation by inducing the differentiation of granulocyte colony-forming units, rhG-CSF has also been reported to have a proliferative effect on several solid tumors as well as hematopoietic malignancies (4-10). Brandstetter et al (17) reported that exogenous rhG-CSF does not affect the proliferation of ovarian carcinoma cells with G-CSF receptor. Tachibana et al (18) reported a bladder cancer cell line that produced G-CSF as an autocrine factor and expressed G-CSF receptor mRNA.…”

Section: Discussionmentioning

confidence: 98%

“…In the present study, both a direct action of rhG-CSF and an indirect action mediated via PBMCs were confirmed. Brandstetter et al (17) reported that the growth stimulation effect of rhG-CSF on ovarian carcinoma cell lines changes with different fetal calf serum concentrations. Thus, our results may have been affected by the in vitro culture conditions, such as plastic substrates or the fetal calf serum concentration.…”

Section: Discussionmentioning

confidence: 99%

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Granulocyte Colony-stimulating Factor may Promote Proliferation of Human Bladder Cancer Cells Mediated by Basic Fibroblast Growth Factor

Ohmi

Matsuyama

Tei

et al. 2003

Scandinavian Journal of Urology and Nephrology

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Granulocyte Colony-stimulating Factor may Promote Proliferation of Human Bladder Cancer Cells Mediated by Basic Fibroblast Growth Factor

Ohmi

Matsuyama

Tei

et al. 2003

Scandinavian Journal of Urology and Nephrology

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“…Postoperatively, WBC count continued to remain elevated because the tumor was [2] kept intact and reached a maximum of 137000/mm 3 . After administration of sorafenib and S-1, however, serum and urinary concentration of G-CSF decreased to less than half the initial levels.…”

Section: Discussionmentioning

confidence: 99%

“…As shown in Fig. 4, the transcription of G-CSF receptor was detected using the two described primers [1,2]. Peritoneal effusion concentration of G-CSF was 5960 pg/ml, suggesting that the tumor was consistent with unclassified RCC producing G-CSF.…”

Section: Case Reportmentioning

confidence: 99%

Combination therapy with sorafenib and S-1 for renal cell carcinoma producing granulocyte colony-stimulating factor

et al. 2010

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We present the first case report of the use of sorafenib and S-1 for the treatment of renal cell carcinoma (RCC) producing granulocyte colony-stimulating factor (G-CSF). This entity is clinically rare and has a poor outcome. A 78-year-old Japanese man presented with macrohematuria, left flank pain, and a palpable mass. Laboratory data showed marked leukocytosis with increased serum and urinary G-CSF. The histopathological diagnosis was unclassified RCC. New combination therapy with sorafenib and S-1 exerted a therapeutic effect and apparently decreased serum and urinary G-CSF levels, although the patient died of gastrointestinal perforation. The use of combined sorafenib and S-1 may be worthy of consideration in the treatment of RCC producing G-CSF.

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“…However, the results of studies on G-CSF-induced tumor growth are controversial. Recently, some studies reported that G-CSF stimulates the growth of tumor cells such as colon cancer cells [8], small lung cancer cells [9], skin carcinoma cells and astrocytoma cells [10] [11], In contrast, Brandstetter et al reported that G-CSF does not exhibit any effect on the proliferation of ovarian carcinoma cell lines or tumor samples despite presence of the G-CSF receptor in the tested cell lines and biopsies [12]. Moreover, G-CSF inhibits tumor growth in a B16-BL6 melanoma cell transplanted mice model [13].…”

Section: Introductionmentioning

confidence: 99%

Granulocyte Colony-Stimulating Factor Enhances the Anticancer Effects of Cisplatin against Lung Cancer by Promoting Angiogenesis

Li¹,

Ohno²,

Funaguchi³

et al. 2017

ALC

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The G-CSF is used as a therapeutic drug of the febrile neutropenia in lung cancer chemotherapy, however, there were few reports that showed the effects of combination effects of G-CSF and anticancer drugs against lung cancer. In the present study, we investigated the effects of G-CSF and the combination effects of G-CSF and cisplatin on lung cancer growth. We investigated the effect of G-CSF against the LL-2 and KLN-205 cells by MTT assay and tried to detect the G-CSF receptor by RT-PCR. Next, to analyze the G-CSF effects in vivo, we transplanted the LL-2 into C57BL/6 mice, intraperitoneally administered G-CSF (30 micro/kg/day) with or without cisplatin (5 mg/kg), measured the tumor size and analyzed pathologically by HE and immunostaining. In vitro analyses, G-CSF showed no effects in LL-2 and KLN-205 cells, and RT-PCR revealed no G-CSF receptor mRNA. In vivo analyses, G-CSF alone did not significantly suppress tumor growth. However, concurrent G-CSF administration with cisplatin significantly enhanced the tumor suppressing effect of cisplatin in early stage of tumor growth. The analysis data of vWF immunostaining indicated that the neovascularization in the peripheral region of the tumors was more enhanced in G-CSF treatment mice. ELISA assay revealed that G-CSF did not influence the serum concentration of TNF-alpha and IL-12 in tumor-bearing mice. This study suggests that concurrent (combination) administration of cisplatin with G-CSF is a safe and effective method for enhancing anticancer effects and reducing chemotherapeutic agent-induced myelosuppression.

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Granulocyte colony-stimulating factor (G-CSF) receptor gene expression of ovarian carcinoma does not correlate with G-CSF caused cell proliferation

Cited by 12 publications

References 51 publications

Granulocyte Colony-stimulating Factor may Promote Proliferation of Human Bladder Cancer Cells Mediated by Basic Fibroblast Growth Factor

Granulocyte Colony-stimulating Factor may Promote Proliferation of Human Bladder Cancer Cells Mediated by Basic Fibroblast Growth Factor

Combination therapy with sorafenib and S-1 for renal cell carcinoma producing granulocyte colony-stimulating factor

Granulocyte Colony-Stimulating Factor Enhances the Anticancer Effects of Cisplatin against Lung Cancer by Promoting Angiogenesis

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