1990
DOI: 10.1182/blood.v75.1.17.17
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Granulocyte colony-stimulating factor stimulates human mature neutrophilic granulocytes to produce interferon-alpha

Abstract: Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein hormone that specifically stimulates both production and functional activation of neutrophils, while interferon-a (IFN-a) is known to suppress myelopoiesis, including neutrophil production in vivo and in vitro. On a possibility that IFN-a may operate as one of the inhibitoryfeedback factors in neutropoiesis, we examined whether neutrophils produce IFN-a in response to G-CSF. Northern blot analysis showed that messenger RNA (mRNA) for human IFN-a 1… Show more

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Cited by 79 publications
(23 citation statements)
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“…Monocytes and neutrophils share the same stem cell, and like monocytes, neutrophils have the same capacity to phagocytize or kill bacteria via various proteases and reactive oxygen metabolites. In addition to these functions, recent studies have shown that the neutrophil can produce various cytokines, such as TNFa, IL-1, IL-6, G-CSF, M-CSF, and IFNa (8)(9)(10)(11)(12). The production of these cytokines by neutrophils at sites of inflammation may play a significant role in the subsequent evolution of either acute or chronic inflammation.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Monocytes and neutrophils share the same stem cell, and like monocytes, neutrophils have the same capacity to phagocytize or kill bacteria via various proteases and reactive oxygen metabolites. In addition to these functions, recent studies have shown that the neutrophil can produce various cytokines, such as TNFa, IL-1, IL-6, G-CSF, M-CSF, and IFNa (8)(9)(10)(11)(12). The production of these cytokines by neutrophils at sites of inflammation may play a significant role in the subsequent evolution of either acute or chronic inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…Although the neutrophil can participate in the inflammatory process by the release of reactive oxygen metabolites, preformed proteases, and lipid chemotaxins (LTB4 and PAF), it has previously been considered a terminally differentiated cell with limited ability to synthesize de novo protein. Recently, however, the neutrophil has been shown to synthesize and express a number of cytokines, such as TNFa, IL-1, IL-6, G-CSF, M-CSF, and IFN(z (8)(9)(10)(11)(12).…”
mentioning
confidence: 99%
“…In response to an appropriate viral stimulus, probably any cell can produce IFN‐α and/or IFN‐β. Within the immune system, monocytes and macrophages (87–92), neutrophils (93), myeloid (CD8α – CD11c high ) and lymphoid (CD8α + CD11c high ) DCs (94–96), plasmacytoid DC (PDC) precursors [CD11c int (mouse) or CD11c neg (human)] (97), NK cells (98), and T cells (99) have been described to release type I IFN in response to mitogenic, viral, and/or microbial stimuli (see for microbial stimuli and the respective references). Some cell types show a selective expression of IFN‐β or of some IFN‐α subtypes in response to certain stimuli (100–103).…”
Section: Producers Of Ifn‐α/βmentioning
confidence: 99%
“…Bone marrow is a heterogeneous suspension of cells composed mainly of erythroid, lymphoid, and myeloid cells plus a small proportion of megakaryoctytes and connective tissue. Although accumulating evidence has demonstrated that mature, blood-borne leukocytes are capable of generat- ing a number of stimulus-specific cytokines (2,6,15,16,26,29,30), relatively little is known about the expression of cytokines from the committed but not yet fully differentiated maturation and storage compartment of bone marrow. Although a large research effort has been focused on the production and effects of colony-stimulating factors, relatively little research has evaluated the presence and significance of other cytokines (3,7,11,29) such as IL-8.…”
Section: Discussionmentioning
confidence: 99%