Granulocyte elastase in assessment of severity of acute pancreatitis

Schölmerich, Jürgen; Hg, Leser; Salm, R.; Lausen, M; Rückauer, K; Schöffel, U.; Lay, L.; Heinisch, Annika; Eh, Farthmann

doi:10.1007/bf01537230

Cited by 150 publications

(18 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Elastase is primarily located in the azurophil granules and is an active component of the phagocytic system of polymorphonuclear leukocytes (26,27). Perivascular infiltration of polymorphonuclear leukocytes in Behfefs patients is well known.…”

Section: Discussionmentioning

confidence: 99%

Plasma Lipoprotein(a) and Its Relationship with Disease Activity in Patients with Behçet’s Disease

Örem

Çimşit²,

Karahan³

et al. 1995

CCLM

View full text Add to dashboard Cite

Summary:Behufs disease is characterized by orogenital ulccrations and ocular lesions, Other features include arthritis, thrombophlebitis, neurological abnormalities and skin lesions. The disease is characterized by a relapsing inflammatory process of unknown aetiology. Lipoprolcin(a) is an LDL-likc particle with a large glycoprotein called apolipoprotein(a) attached to its npolipoprotcin B moiety through one or more clisulphidc bonds. Apolipoprotein(a) is related to plasminogcn from which the cn/yme plasmin, that hydrolyscs fibrin blood clots, is released by tissue plasininogcn activators. The unique structural features of Lp(a) give it the potential for atherogenie and thrombogenic activities. In the present study 35% of patients with /ic j //(.'t'/\s disease were shown to have higher Lp(a) concentrations than the cut-off point (0.30 g/l) for atherosclerosis. Plasma Lp(a) concentrations in the remission period were also found 1ο be lower than during the active period in the same patients (23% decreased). Lp(a) showed significant correlations with acute phase rcaclanls such as crythrocyte sedimentation rate, polymorphonuclcar leukocytes and polymoφhonuclear leukocyte elastase activity. Therefore, it was concluded that the fluclations of plasma Lp(a) levels with the activity of disease may be a contributing risk factor in the development of (hrombogcnic complications in patients with Belief $ disease.In conclusion, we suggest that plasma Lp(a) concentrations be determined for patients with Belter* disease, and that patients with high Lp(a) levels be kept under close controls especially during the active period of the disease, and taken into remission as soon as possible.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma Lipoprotein(a) and Its Relationship with Disease Activity in Patients with Behçet’s Disease

Örem

Çimşit²,

Karahan³

et al. 1995

CCLM

View full text Add to dashboard Cite

show abstract

“…Extensive postischemic adherence of polymorphonuclear leukocytes to the endothelium of postcapillary venules and the ensuing migration into the interstitium have also been verified in clinical studies of AP [33, 81, 82, 83]. The concentrations of polymorphonuclear cell-derived elastase are increased in patients with AP and correlate with the severity of the attack [82, 83].…”

Section: Ischemia/reperfusion Injury Of the Pancreasmentioning

confidence: 95%

“…The concentrations of polymorphonuclear cell-derived elastase are increased in patients with AP and correlate with the severity of the attack [82, 83]. The elastase concentration proved significantly lower in edematous pancreatitis in comparison to necrotizing pancreatitis [84].…”

Section: Ischemia/reperfusion Injury Of the Pancreasmentioning

confidence: 99%

Ischemia/Reperfusion-Induced Pancreatitis

Sakorafas

Tsiotos

Sarr³

2000

Dig Surg

101

View full text Add to dashboard Cite

Background/Aim: The pancreas is an organ highly susceptible to ischemic damage. This discussion reviews the role of ischemia as an etiologic factor in acute pancreatitis. Methods: Literature review. Results: The susceptibility of the pancreas to ischemia/reperfusion injury has been demonstrated in experimental studies and in clinical settings such as cardiopulmonary bypass, hemorrhagic shock, and transplantation of the pancreas. Oxygen free radicals, activation of polymorphonuclear leukocytes, failure of microvascular perfusion, cellular acidosis, and disturbance of intracellular homeostasis appear to be important factors/mechanisms in the pathogenesis of ischemia/reperfusion-induced acute pancreatitis. In clinical practice, the diagnosis of ischemic pancreatitis is difficult and often delayed, especially during the postoperative period after cardiac or major vascular surgery. Conclusions: Ischemia appears to be one important factor in acute pancreatitis. The management of ischemic pancreatitis is similar to that of acute pancreatitis of any etiology.

show abstract

“…Neutrophil-induced tissue destruction, in vivo, rests on the release of proteolytic enzymes and the production of free radical metabolites [30]. Polymorphonuclear elastase, which is a specific marker for neutrophil activation, has been found to be higher in the serum of patients with severe pancreatitis or a fatal outcome than in patients with mild disease [31, 32, 33]. …”

Section: Pathogenesis Of Acute Pancreatitismentioning

confidence: 99%