Granulocyte products

How do we…consistently provide high‐dose granulocyte products for transfusions in neutropenic patients?

“…21 The use of hetastarch in conjunction with Spectra Optia apheresis in our study was able to generate a product in which 96.5% of units contained ANC yields greater than the 4.0 Â 10 10 granulocyte per unit while 97.6% of units contained RBC volume less than 30 mL. 3,7 Collections typically take 2-3 h but may take longer depending on intake procedures, staffing levels, and alterations to the standard collection rate. 22 In this study, all collected products were able to be transfused within 24-h of collection with a median time of 7.0 h between the end of collection and start of transfusion.…”

“…The use of hetastarch to generate a better interface between the granulocyte and RBC components has been shown to improve granulocyte yield and minimize RBC contamination 21 . The use of hetastarch in conjunction with Spectra Optia apheresis in our study was able to generate a product in which 96.5% of units contained ANC yields greater than the 4.0 × 10 10 granulocyte per unit while 97.6% of units contained RBC volume less than 30 mL 3,7 . Collections typically take 2–3 h but may take longer depending on intake procedures, staffing levels, and alterations to the standard collection rate 22 .…”

“…6 RBC contamination should be kept to no more than 30 mL per unit. 7 The processes described in this study, and outlined in Figure 6, resulted in nearly all the granulocyte products meeting these criteria. Approximately 99% of units contained a granulocyte count equal to or greater than 1.0 Â 10 10 (n = 254).…”

“…Granulocytes may be stored at 20°C–24°C but should be transfused within 24‐h of collection 6 . RBC contamination should be kept to no more than 30 mL per unit 7 . The processes described in this study, and outlined in Figure 6, resulted in nearly all the granulocyte products meeting these criteria.…”