Granulocyte transfusion vs. neutropenia — is there a chance to win this battle?

Szumowski, Artur; Radziwon, Piotr

doi:10.5603/mrj.a2022.0048

Medical Research Journal

2022

DOI: 10.5603/mrj.a2022.0048

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Granulocyte transfusion vs. neutropenia — is there a chance to win this battle?

Artur Szumowski

Piotr Radziwon

Abstract: Bacterial and fungal infections remain a significant cause of morbidity and mortality in patients with prolonged severe neutropenia that results from the treatment of an underlying haematological malignancy.Granulocyte transfusions have been broadly used to prevent and/or treat life-threatening infections in these patients. The purpose of this review was to answer the question, "Are granulocyte transfusions effective in combating hazardous infections in haematology/oncology patients with neutropenia?".

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2024

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Use of Granulocyte Transfusions in the Management of Severe Infections Among Children with Neutropenia

Mielecka-Jarmocik,

Szymbor,

Balwierz

et al. 2024

JPM

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Background/Objectives: Infections remain the leading cause of mortality among neutropenic patients with haematologic malignancies, making effective infection management crucial. Achieving a sufficient neutrophil count is essential for the elimination of pathogens. Granulocyte concentrate (GC) can be a treatment option for neutropenic patients with severe infections. This study aimed to evaluate the efficacy, safety, and impact on survival of GC transfusions in neutropenic children with severe infections treated over the past 13 years in a single centre. Methods: The retrospective study analysed clinical data from 60 children (median age 9.5 years) who received GC transfusions at our centre. Granulocytes were collected by apheresis from donors stimulated with granulocyte colony-stimulating factor. The majority of the patients (70%) were diagnosed with acute leukaemia. The main indications for GC were severe pneumonia (45%) and bacterial sepsis (38.33%). Results: The patients received 1 to 29 GC transfusions for 1 to 70 days, with a median time of administration of 3 days. Neutrophil counts increased to >1000/µL within a median of 5 days. GCs were well tolerated by most patients. One patient presented symptoms of anaphylaxis, the other acute lung injury related to transfusions, and alloimmunisation was reported in one patient. Of the patients analysed, 78.33% survived the infection that justified GC administration. We did not observe significant differences in survival depending on the aetiology of the infection. Conclusions: Based on our research, GC appears to be a beneficiary for neutropenic children with severe infections and reduces infection mortality rates. However, further well-designed randomised trials are needed to define its role in this setting.

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Use of Granulocyte Transfusions in the Management of Severe Infections Among Children with Neutropenia

Mielecka-Jarmocik,

Szymbor,

Balwierz

et al. 2024

JPM

View full text Add to dashboard Cite

show abstract

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Granulocyte transfusion vs. neutropenia — is there a chance to win this battle?

Cited by 1 publication

References 70 publications

Use of Granulocyte Transfusions in the Management of Severe Infections Among Children with Neutropenia

Use of Granulocyte Transfusions in the Management of Severe Infections Among Children with Neutropenia

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