Granulocytic sarcoma of cervix

Ye, Zhongxue; Jiang, Yafen

doi:10.1097/md.0000000000029419

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…Despite the negative lysosome staining, strongly positive cytoplasmic MPO expression was consistent with a myeloid tumour origin and, in combination with the HE findings, was sufficient to provide a diagnosis of GS. Indeed, these results are consistent with those described in other case reports (Brum et al, 2012;Kheirkhah et al, 2021;Rong et al, 2010;Traweek et al, 1993;Ye & Jiang, 2022).…”

Section: Discussionsupporting

confidence: 93%

Solitary eosinophilic granulocytic sarcoma in a dog

Hu,

Xiao,

Zhang

et al. 2024

Veterinary Medicine & Sci

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A 6‐year‐old male golden retriever presented with swelling of the left upper eyelid of 2 months duration, which did not improve following a course of antibiotics. Routine serum biochemistry, complete blood count and diagnostic imaging identified no clinically significant abnormalities. The mass was surgically excised, and histopathologic examination was performed. Eosinophilic granulocytic sarcoma (GS) was diagnosed based on the results of histopathology and immunohistochemistry. This is the first report of GS affecting the eyelid of a dog.

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Section: Discussionsupporting

confidence: 93%

Solitary eosinophilic granulocytic sarcoma in a dog

Hu,

Xiao,

Zhang

et al. 2024

Veterinary Medicine & Sci

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Myeloid Sarcoma as a Presentation of Acute Myeloid Leukemia and Blastic Phase in the Course of Chronic Myeloid Leukemia: A Case Report and Literature Review

Giordano

Sawicki²,

Pilch

et al. 2023

JCM

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Background: Myeloid sarcoma (MS), also known as granulocytic sarcoma or chloroma, is a rare disease entity characterized by the emergence of an extramedullary tumor, which may be antecedent, coexisting, or manifest secondarily to an ongoing malignancy of lymphoid origin. Owing to its low prevalence, scientific reports addressing this matter comprise mainly retrospective studies with a limited number of participants, rather low-quality research, and only few case reports. Despite MS’s rarity, the need for enhancing their diagnostic tools and refinement of their therapeutic regimens is broadly recognized among physicians. Case summary: In this case series, we present the clinical histories of two patients diagnosed with MS. The former (Case 1) exhibited MS of the sternum alongside chronic myeloid leukemia (CML), while in case of the latter (Case 2) MS presented as the initial manifestation of a current acute myeloid leukemia (AML). Treatment for both patients included chemotherapy (CHTH) and radiation (RT); however, patient 1 with CML died due to cardiorespiratory insufficiency secondary to an infection, while patient 2 is in clinical remission (CR) for 16 months since their MS diagnosis. Furthermore, a comprehensive analysis of previously reported cases was conducted which incorporated MS in patients with AML and CML. Conclusion: The objective of this report was to emphasize the heterogeneity among the clinical manifestations of MS, to underline the relevance of the histopathological and molecular diagnostic tools in opting for the appropriate therapy, and that, in spite of it occurring rather uncommonly, physicians should think of MS in the presence of pathological masses in patients under risk of hematological malignancies.

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Cervical Granulocytic Sarcoma Without Acute Leukemia: A Case Report and Review of 42 Additional Cases

Zhu,

Tao,

Ruan

et al. 2024

Cureus

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Granulocytic sarcoma (GS), also known as extramedullary myeloid tumor, is a rare malignant neoplasm composed of immature myeloid cells. Although it is most commonly associated with acute myeloid leukemia (AML), a subset of GS cases can occur prior to the development of AML. GS can present in a variety of extramedullary locations, including bone, skin, lymph nodes, and the female reproductive system. We report the case of a 45-year-old Asian female patient who presented to our hospital in July 2015 with a three-month history of left-sided lumbago. A contrast-enhanced computed tomography (CT) scan of the abdomen and pelvis revealed a retroperitoneal mass and an enlarged uterine cervix with an accompanying 57×52 mm mass. A cervical biopsy confirmed the diagnosis of GS. Immunohistochemical (IHC) analysis of the biopsy showed that the neoplastic cells were positive for CD34, CD15, CD33, CD43, lysozyme, and myeloperoxidase. The patient was subsequently treated with an idarubicin and cytarabine-based regimen for four cycles. A follow-up CT scan of the abdomen and pelvis demonstrated a significant reduction in the size of the previous lesions. Unfortunately, the patient passed away in April 2016 due to a cerebral hemorrhage. In this report, we also review 42 additional cases to discuss the pathological characteristics, treatment strategies, and clinical outcomes of GS.

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Granulocytic sarcoma of cervix

Cited by 3 publications

References 12 publications

Solitary eosinophilic granulocytic sarcoma in a dog

Solitary eosinophilic granulocytic sarcoma in a dog

Myeloid Sarcoma as a Presentation of Acute Myeloid Leukemia and Blastic Phase in the Course of Chronic Myeloid Leukemia: A Case Report and Literature Review

Cervical Granulocytic Sarcoma Without Acute Leukemia: A Case Report and Review of 42 Additional Cases

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