Granuloma Annulare at Sites of Healing Herpes Zoster

Folliculocentric Herpes: A Clinicopathological Study of 28 Patients

“…8 A specific form of small histiocyte has been identified in the inflammatory infiltrate surrounding herpetic bullae in mucosal surfaces and skin of herpetic lesions; this histiocyte is also tropic to the hair follicle in cases of herpetic folliculitis and is postulated to be involved in antigen presentation, in the destruction of infected keratinocytes, or in delivery of viral DNA to follicular structures. The non-infective sequelae of herpes zoster infection include segmental scarring, 11 comedone formation, 12 granulomatous vasculitis, 13,14 milia, 15 lichen planus, granulomatous inflammation of sarcoidal, 16-18 tuberculoid 19 or granuloma annulare-like subtypes, 16,[20][21][22][23] psoriatic lesions, 24 morphea, 25 lymphocytoma cutis, 26,27 chronic lymphocytic leukemia, 28 and Kaposi sarcoma. Antigenic homology of an endogenous 72-kd heat shock protein within the hair follicle with that of a herpetic heat shock protein has been described.…”

Cutaneous T-cell lymphoma sparing resolving dermatomal herpes zoster lesions: an unusual phenomenon and implications for pathophysiology

“…1,2 Paraproteinemia most commonly includes IgG lambda light chains. 1,3 In most patients, the paraproteinemia is of undetermined significance, but it has been associated with multiple myeloma in 10% of patients. 1,4 The treatment of scleromyxedema is frequently disappointing, and the evidence of therapeutic efficacy is largely anecdotal.…”

“…1,3 In most patients, the paraproteinemia is of undetermined significance, but it has been associated with multiple myeloma in 10% of patients. 1,4 The treatment of scleromyxedema is frequently disappointing, and the evidence of therapeutic efficacy is largely anecdotal. 5 Although some treatments have focused on improving the appearance of skin lesions, other treatments have targeted the associated plasma cell dyscrasia.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12] We present a unique phenomenon in which an area of healed herpes zoster was spared by erythrodermic cutaneous T-cell lymphoma (CTCL). Further immunohistochemical analysis of this phenomenon suggests a role for Langerhans cells (LC) in the pathobiology of epidermotropism in CTCL.…”

Viral diseases

“…350 If the vasculitis is severe, necrotizing lesions will be present. 323,352,353 These factors, as well as secondary infection, contribute to the scarring which sometimes ensues. 323,352,353 These factors, as well as secondary infection, contribute to the scarring which sometimes ensues.…”