Granuloma annulare in a Patient with Malignant Lymphoma

Abstract

We describe the case of a 69-year-old man with malignant lymphoma who developed granuloma annulare on his fingers. The number of cutaneous nodules increased when a recurrence of lymphoma was demonstrated during the course of disease. Granulomatous lesions disappeared after the fifth cycle of chemotherapy with CHOP (cyclophosphamide, Adriamycin, vincristine, prednisolone). The coexistence of these two diseases is relatively rare. The clinical features seen in this case, however, might suggest that granuloma annulare is a generalized granulomatous reaction induced by malignant lymphoma

Myelodysplastic Syndrome Presenting as Generalized Granulomatous Dermatitis

“…Cutaneous presentations can vary and include recalcitrant dermatitis. 2 Several reports have described granulomatous dermatitis in the setting of underlying malignant conditions, including lymphoma, 3,4 leukemia, [5][6][7][8] and various solid organ malignancies.…”

The granulomatous reaction pattern

“…The hands, feet, arms, and legs are the sites of predilection in some 80% of cases. [379][380][381][382][383][384][385][386][387][388] In these conditions, the clinical presentation may be atypical. 294 The generalized form accounts for approximately 15% of cases.…”

Granuloma annulare with a mycosis fungoides–like distribution and palisaded granulomas of CD68-positive histiocytes

“…4,5 GA and clinically atypical GA have been reported in patients with lymphomas. [6][7][8][9] Clinically atypical GA and necrobiosis lipoidica have also been associated with systemic diseases. 10 The pathogenesis of GA is uncertain.…”