Granuloma Annulare-Like Pattern in Mycosis Fungoides

Garrie, Stuart A.

doi:10.1001/archderm.1972.01620080043012

Cited by 29 publications

(13 citation statements)

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“…Granulomas were sarcoid-like in all biopsy specimens ( Figure 6). Other patterns of granulomatous reactions, such as granuloma annulare-like, palisaded, or necrobiotic granuloma, as reported in the literature, [27][28][29][30] were not found in our series. In 70% of the CTCL cases, the infiltrates contained histiocytic giant cells displaying 10 or more nuclei (Figure 11).…”

Section: Commentsupporting

confidence: 48%

Granulomatous Mycosis Fungoides and Granulomatous Slack Skin

Kempf¹,

Ostheeren-Michaelis²,

Paulli³

et al. 2008

Arch Dermatol

176

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Section: Commentsupporting

confidence: 48%

Granulomatous Mycosis Fungoides and Granulomatous Slack Skin

Kempf¹,

Ostheeren-Michaelis²,

Paulli³

et al. 2008

Arch Dermatol

176

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“…The presence of additional skin lesions with typical MF features and the detection of T-cell clones enable this variant to be distinguished from granuloma annulare. 78,79 The third pattern is typified, as its name implies, by the presence of multinucleated giant cells, usually of the foreign body type. Langerhans' cells and Touton cells have also been described ( fig.…”

Section: Granulomatous Mf and Granulomatous Slack Skinmentioning

confidence: 99%

Clinicopathological spectrum of mycosis fungoides

Kazakov

Burg

Kempf

2004

Acad Dermatol Venereol

241

225

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Cutaneous lymphomas represent a heterogeneous group of T-, NK- and B-cell neoplasms, with mycosis fungoides (MF) being the most common subtype. MF has a plethora of clinicopathological manifestations. Many variants of this lymphoma differ substantially from the 'classical' Alibert-Bazin disease and are therefore sometimes referred to as 'atypical' forms of the disease. This review addresses the whole clinicopathological spectrum of mycosis fungoides with respect to epidemiology, clinical, histopathological, immunophenotypic and genotypic features and the clinical course and prognosis of its variants: classical, erythrodermic, follicular, syringotropic, bullous/vesicular, granulomatous, poikilodermic, hypo- and hyperpigmented, unilesional, palmoplantar, hyperkeratotic/verrucous, vegetating/papillomatous, ichthyosiform, pigmented purpura-like, pustular and mucosal involvement in MF.

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“…Granulomas are seen in 6.3% of cases of MF and they usually are epithelioid, non‐necrotizing, and many times sarcoidal . Some studies, nevertheless, have found a predominance of “interstitial and perivascular granulomas with multinucleated giant cells and eosinophils.” Granuloma annulare‐like, palisaded, or necrobiotic granulomas are also reported as associated with MF . Giant cells are evidenced in most granulomatous MF .…”

Section: Discussionmentioning

confidence: 99%

“…16 Granuloma annulare-like, palisaded, or necrobiotic granulomas are also reported as associated with MF. [19][20][21][22] Giant cells are evidenced in most granulomatous MF. 17 The amount of granulomas in a certain biopsy of granulomatous MF also varies: in some cases the granulomatous reaction can be very extensive, so that the histopathological signs of MF are easily missed.…”

Section: Discussionmentioning

confidence: 99%

Plasmacytoid dendritic cells in granulomatous variant of mycosis fungoides

Fernández-Flores

2019

J Cutan Pathol

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Introduction Granulomatous mycosis fungoides (MF) is a rare variant in which granulomas are associated with other typical signs of MF. Its prognosis is worse than that of classical MF. Plasmacytoid dendritic cells (PDCs) are a subset of interferon‐producing dendritic cells that link the innate and the adaptative immune responses. They have also been related to tolerance to certain tumors such as melanoma. Materials and methods In this article, we examined for the presence of CD123+ PDC in six cases of granulomatous MF from our archives. Results We found clusters of 10 or more positive cells in three of six cases of granulomatous MF (two women and a man, in their sixth and seventh decade). Although in two of these three cases the granulomatous response was extensive, in the other, it only represented 10% of the infiltrate of the biopsy. In all three cases, the granulomas were epithelioid, sarcoidal type. Conclusions CD123+ PDC can be identified in granulomatous MF. The pathogenic and prognostic role of this finding requires further clarification.

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Granuloma Annulare-Like Pattern in Mycosis Fungoides

Cited by 29 publications

References 0 publications

Granulomatous Mycosis Fungoides and Granulomatous Slack Skin

Granulomatous Mycosis Fungoides and Granulomatous Slack Skin

Clinicopathological spectrum of mycosis fungoides

Plasmacytoid dendritic cells in granulomatous variant of mycosis fungoides

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