Granuloma Formation in Schistosoma japonicum Infected Nude Mice: the Effects of Reconstitution with L3T4+ or Lyt2+ Splenic Cells

Tissue responses in experimental schistosomiasis japonica in the pig: a histopathologic study of different stages of single low- or high-dose infections.

“…34 The lack of large exudative-productive granulomas in our study may also be the result of modulation of the tissue response, i.e., a reduction of the size of granulomas formed around recently laid eggs with viable mature miracidia, which occurs with the progression of infection in schistosomiasis. 35,36 Our results suggest that early egg destruction contributes to reduced granuloma formation in pigs, but conclusions concerning the mechanisms involved are difficult to draw from this study due to the very few morphologically intact eggs present in the liver granulomas.…”

Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni.

“…Fecal egg numbers (21) were evaluated in stools collected during a 24-hr period immediately prior to termination of the experiment, and tissue egg counts were performed on digested liver and intestines as described (21 (24), was used at a concentration (10 ,ug/ml) previously shown to give optimal proliferative responses in splenocytes from 8-week infected mice. After 24 hr, culture supernatants were harvested and assayed for their concentration of cytokines by two-site ELISA using either a polyclonal antibody plus a monoclonal antibody (IFN-y assay) (25) or two monoclonal antibodies recognizing distinct epitopes (IL-5 assay) (15,25).…”

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

“…This response is greatly reduced in mice treated with anti-CD4 + (83) and can be restored to athymic mice by adoptive transfer of purifi ed CD4 + T-cell populations (84). Induced by ova swept from the vasculature (where the adult worms reside) into tissues (e.g.…”