Granuloma hialinizante de pulmão recidivante

Arruda, Guilherme D’Andréa Saba; Carvalho, Paulo César Ribeiro de; Andrade, Mara Patrícia Guilhermino de; Cusmanich, Maurício Campos; Bandeira, Gustavo Andrada; Tozaki, Felipe Shigueo Passos

doi:10.1590/s1806-37132010000500019

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…[3] On the other hand, a solitary lesion may remain relatively stable over a long interval. Multiple lesions have a worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Up to 25% of patients with PHG are asymptomatic at the time of presentation. [3] The remainder may present with mild symptoms of chest pain, dry cough, fever, dyspnea, sinusitis, and occasionally hemoptysis. The exact etiology of PHG is unknown, although a proposed mechanism is an exaggerated immune response to the antigenic stimuli associated with various infections and immune-mediated conditions that affect the lung.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura

Coleman

Nassar

McComb

2014

Journal of Clinical Imaging Science

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Pulmonary hyalinizing granuloma (PHG) is a rare, benign lung disease of unknown etiology. It manifests as discrete, rounded nodules within the lung parenchyma. A 39-year-old woman presented for investigation after pulmonary nodules were found incidentally. Chest computed tomography showed multiple, discrete, non-enhancing pulmonary nodules bilaterally. Positron emission tomography (PET) was negative. Biopsy demonstrated a non-specific lymphoplasmacytic infiltrate. Open resection yielded two nodules consistent with hyalinizing granulomas. The differential for multiple pulmonary nodules is broad. PET scan can help rule out metastatic disease, although some cancers are not hypermetabolic on PET. Furthermore, some non-malignant conditions, including hyalinizing granuloma, can show increased activity on PET. PHG should be included in the differential of multiple pulmonary nodules, especially if nodule stability can be demonstrated and/or needle biopsies are non-diagnostic. Associated immune-mediated conditions, such as idiopathic thrombocytopenic purpura (ITP) in our patient, may also favor HG. In this case report we find an association between PHG and ITP.

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“…[3] On the other hand, a solitary lesion may remain relatively stable over a long interval. Multiple lesions have a worse prognosis.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura

Coleman

Nassar

McComb

2014

Journal of Clinical Imaging Science

View full text Add to dashboard Cite

show abstract

“…Clinically, PHG can be asymptomatic (25% of all patients) or present with dry cough, fever, dyspnea and hemoptysis [3].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Hyalinizing Granuloma: A Case Report

Amorim¹,

Silva²,

Filho³

2016

OJTS

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Pulmonary hyalinizing granuloma: a multicenter study of 5 new cases and review of the 135 cases of the literature

et al. 2016

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Pulmonary hyalinizing granuloma (PHG) is a rare disease characterized by single or multiple benign lung nodules mimicking lung neoplasma. Histologic analysis reveals homogenous hyaline lamellae, usually surrounded by collection of plasma cells, lymphocytes and histiocytes in a perivascular distribution. The clinical and radiological findings have been described in small series, but the long-term outcomes have rarely been reported. The objectives were to describe the clinical, radiological and outcomes of PHG in new cases and through a literature review. Patients with PHG were found by a multicenter search among French departments of internal medicine, pulmonology and anatomo-pathology. Review of the literature was made through the National Library of Medicine's MEDLINE database using keywords "hyalinizing granuloma." Five news cases and 135 cases of the literature were found. There were 82 men and 57 women, mean age at the diagnosis 44.6 years (15-83). Patients were frequently asymptomatic (n = 39, 27.4 %). The nodule was unique in 37 cases (28.9 %) and multiple in 91 cases (71.1 %). 18FDG PET scan revealed hypermetabolism of the nodule in 9/15 cases (60 %). A systemic disease was associated in 65 cases (mainly mediastinal and retroperitoneal fibrosis, autoimmune, tumoral or infectious disease or thromboembolism). The outcomes were evaluated in 73 patients when follow-up was available: 14 patients had a surgical resection of the nodule. Forty-five patients did not receive any immunosuppressive drug. Among these patients, 2 improved, 29 were stable and 14 worsened. Corticosteroids were used as a monotherapy in 19 patients and led to radiological improvement in 8 cases, stabilization in 8 cases and worsening in 3 cases. Five patients were treated with corticosteroids and at least one immunosuppressive drug and 4 patients improved. PHG is a rare benign disease, mimicking lung neoplasma, frequently associated with systemic diseases.

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Granuloma hialinizante de pulmão recidivante

Cited by 4 publications

References 9 publications

Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura

Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura

Pulmonary Hyalinizing Granuloma: A Case Report

Pulmonary hyalinizing granuloma: a multicenter study of 5 new cases and review of the 135 cases of the literature

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