Granulomas in Small Bowel Crohnʼs Masking Whippleʼs Disease

Mousa, Omar Y.; Mousa, Yazan S; Nimri, Sarah M. Al

doi:10.14309/00000434-201710001-02428

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While such colonization is likely the case in our patient, Tropheryma whipplei has also been linked to acute gastroenteritis in young children [ 75 ]. Few case reports suggest that Tropheryma whipplei infection can mimic CD [ 76 , 77 , 78 ], but a general association with IBD or an increased carrier frequency in CD patients have not been reported.…”

Section: Discussionmentioning

confidence: 99%

Is Autologous Fecal Microbiota Transfer after Exclusive Enteral Nutrition in Pediatric Crohn’s Disease Patients Rational and Feasible? Data from a Feasibility Test

Hoelz¹,

Heetmeyer²,

Tsakmaklis

et al. 2023

Nutrients

View full text Add to dashboard Cite

Background: Exclusive enteral nutrition (EEN) is a highly effective therapy for remission induction in pediatric Crohn’s disease (CD), but relapse rates after return to a regular diet are high. Autologous fecal microbiota transfer (FMT) using stool collected during EEN-induced clinical remission might represent a novel approach to maintaining the benefits of EEN. Methods: Pediatric CD patients provided fecal material at home, which was shipped at 4 °C to an FMT laboratory for FMT capsule generation and extensive pathogen safety screening. The microbial community composition of samples taken before and after shipment and after encapsulation was characterized using 16S rRNA amplicon sequencing. Results: Seven pediatric patients provided fecal material for nine test runs after at least three weeks of nutritional therapy. FMT capsules were successfully generated in 6/8 deliveries, but stool weight and consistency varied widely. Transport and processing of fecal material into FMT capsules did not fundamentally change microbial composition, but microbial richness was <30 genera in 3/9 samples. Stool safety screening was positive for potential pathogens or drug resistance genes in 8/9 test runs. Conclusions: A high pathogen burden, low-diversity microbiota, and practical deficiencies of EEN-conditioned fecal material might render autologous capsule-FMT an unsuitable approach as maintenance therapy for pediatric CD patients.

show abstract