Granulomatous angiitis of the CNS causing spontaneous intracerebral haemorrhage: the importance of leptomeningeal biopsy

Hunn, Martin; Robinson, Simon; Wakefield, Len; Mossman, Stuart; Abernethy, David

doi:10.1136/jnnp.65.6.956

Cited by 17 publications

(11 citation statements)

References 5 publications

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“…Intracerebral hemorrhages may accompany the ischemic lesions in PACNS. 2,3,6,13,18) The rate of hemorrhages associated with lesions in observed cases of PACNS was 4%. 4) The hemorrhages often involved cortical and subcortical regions and no risk factors predisposing to hemorrhages were identified.…”

Section: Discussionmentioning

confidence: 90%

Primary Angiitis of the Central Nervous System Mimicking Tumor-Like Lesion -Case Report-

Tanei

Nakahara

Takebayashi

et al. 2011

Neurol. Med. Chir.(Tokyo)

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A 60-year-old man presented with a rare case of primary angiitis of the central nervous system mimicking a tumor-like lesion and manifesting as slight disorientation, left hemiparesis, and motor aphasia. Computed tomography showed multiple low density lesions in the left frontal lobe, brain stem, and right parietal lobe. Magnetic resonance images revealed a slightly enhanced mass lesion in the right parietal lobe with surrounding brain edema. Serum, cerebrospinal fluid, and other image examinations did not show any abnormal findings, so surgical removal of the right parietal mass was performed. Histological examination revealed that the mass consisted of hemorrhagic infarction without cellular atypia. Proliferations of endothelial cells in small and medium arteries, and infiltration of macrophages in the perivascular space were detected in the infarction tissues. The histological diagnosis was primary angiitis of the central nervous system.

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Section: Discussionmentioning

confidence: 90%

Primary Angiitis of the Central Nervous System Mimicking Tumor-Like Lesion -Case Report-

Tanei

Nakahara

Takebayashi

et al. 2011

Neurol. Med. Chir.(Tokyo)

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“…The cortico-subcortical topography of these microbleeds is like that of the histopathological distribution of the lesions found in PCNSA. Petechial haemorrhage is not highlighted by traditional T1/T2-weighted sequences but is clearly obvious on the T2*-weighted sequence (Greenberg et al 1996;Hunn et al 1998;Schmidley 2000;Aoki et al 2002;Hakan et al 2002).…”

Section: Petechial Haemorrhagementioning

confidence: 93%

Primary Central Nervous System Angiitis

Bouhaouala

Naggara

Ghorbel

et al. 2011

Systemic Vasculitis

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“…These rates of poor outcomes may have reflected a case-selection bias. Prospective observational studies indicate that the majority of patients with extracranial cervical arterial dissections have a good or excellent outcome [8,16,57,61,[88][89][90]. One prospective, multicenter study found a mortality rate of 4% in patients with cervical carotid artery dissections [7].…”

Section: Prognosismentioning

confidence: 97%

“…Cerebral infarction, caused by occlusion of mediumsized arteries, affects the cortical or deep gray matter, or the subcortical white matter if the small vessels are involved [107,143]. Areas of ischemia can be scattered throughout the CNS, with some associated with discrete foci of hemorrhage [90,144]. Intracerebral hemorrhage was found in 4% (4 of 108) patients in one series [144].…”

Section: Primary Cns Vasculitis (Primary Angiitis Of the Nervous System)mentioning

confidence: 99%

Non-Atherosclerotic Vascular Disease in the Young

Camilo

Goldstein

2005

J Thromb Thrombolysis

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There are a large variety of non-atherosclerotic causes of ischemic stroke in the young. Arterial dissection, most commonly associated with non-traumatic causes, is among the most common. Both the carotid and vertebrobasilar circulations can be affected. The vasculitidies represent a rare, but potentially treatable series of conditions that can lead to stroke through diverse mechanisms. Moyamoya is a nonatherosclerotic, noninflammatory, nonamyloid vasculopathy characterized by chronic progressive stenosis or occlusion of the distal internal carotid arteries and/or proximal portions of the middle and/or anterior cerebral arteries. Moyamoya can be idiopathic (moyamoya disease) or the result of other conditions. An appreciation of the unusual causes of stroke in the young is important when considering secondary prevention measures.

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Granulomatous angiitis of the CNS causing spontaneous intracerebral haemorrhage: the importance of leptomeningeal biopsy

Cited by 17 publications

References 5 publications

Primary Angiitis of the Central Nervous System Mimicking Tumor-Like Lesion -Case Report-

Primary Angiitis of the Central Nervous System Mimicking Tumor-Like Lesion -Case Report-

Primary Central Nervous System Angiitis

Non-Atherosclerotic Vascular Disease in the Young

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