Granulomatous appendicitis in children: A single institutional experience

Abstract

GA in children is a rare entity, with incidence of 1.04% and male preponderance in our series. Idiopathic causes were the most common followed by Yersinia enterocolitis and CD. Although majority remained asymptomatic, IBD should be ruled out in case of recurrence of pain or alteration of bowel habit. Therefore, a long-term follow-up (at least for 5 years) of idiopathic GA is suggested in children.

Differential Diagnosis of the Granulomatous Appendicitis: Retrospective Analysis of Sixteen Cases

“…[4,7,11,12] On the other hand, the most common causes of infectious GAp are Yersinia spp., Lycobacterium spp., Actinomyces spp., Schistosoma spp., Histoplasma spp., Candida spp., Aspergillus spp., Strongyloides spp., Campylobacter spp., Toxoplasma spp., Brucella spp., and other parasitic diseases. [3][4][5][6]13] Eosinophilic granuloma that is characterized by granulomatous inflammation are generally considered to be an indirect indicator for parasitic infections, such as strongyloidiasis, schistosomiasis and enterobiasis. [4,13] We think that it would be more appropriate to include eosinophilic granulomas into the infectious group.…”

“…Although some authors continue to argue otherwise, there is no underlying cause in the majority of patients, which is defined as idiopathic GAp. [3] AbdullGaffar et al [4] have claimed that the factors causing secondary GAp are geographically distributed. Crohn's disease and Yersinia spp.…”

“…[1,2] Apart from these known trigger factors of AAp, one of tween 0.1% and 2%. [3][4][5] Although many benign or malignant diseases may cause GAp, Crohn's disease, Yersinia spp., and Mycobacterium spp. are the most common specific causes of GAp.…”

“…are the most common specific causes of GAp. [3] However, in majority of patients with GAp, a specific factor that may cause granulomatous inflammation cannot be identified, which is called idiopathic GAp. [3,6,7] TB is one of the most important causes of GAp in endemic regions, such as some areas of the Turkey.…”

“…[3] However, in majority of patients with GAp, a specific factor that may cause granulomatous inflammation cannot be identified, which is called idiopathic GAp. [3,6,7] TB is one of the most important causes of GAp in endemic regions, such as some areas of the Turkey. Therefore, TB is among the most emphasized diseases in the differential diagnosis of GAp.…”