Granulomatous arteritis in cutaneous lesions of Churg–Strauss syndrome

Abstract

Granulomatous arteritis as identified in the extracutaneous lesions can also be found in subcutaneous CSS lesions presenting with livedo reticularis and/or subcutaneous nodules.

Spectrum of Cutaneous Vasculitis in Eosinophilic Granulomatosis With Polyangiitis (Churg–Strauss)

“…The features of eosinophilic vasculitis of muscular vessels (Fig. 15,16 Subcutaneous muscular vessel vasculitis that clinically presents as livedo reticularis or subcutaneous nodules is rarely observed in EGPA; however, a deep subcutaneous incisional biopsy should be performed to locate arteritis/phlebitis in the deep subcutis (Fig. Livedo reticularis (Fig.…”

Eosinophilic granulomatosis with polyangiitis (Churg–Strauss)

“…The pathology findings also depend on the site of tissue sampling and are often indistinguishable from other forms of AAVs; therefore, they should always be considered in a given clinical setting [32]. Skin biopsy specimens often show leukocytoclastic vasculitis surrounded by eosinophils and occasionally polymorphonuclear leukocytes and granulomas [28,34]. Nerve biopsy may demonstrate epineural necrotizing vasculitis with accompanying lymphocytes and eosinophil infiltrates [33].…”

Pathology of the Cutaneous Vasculitides: A Comprehensive Review

“…While the vasculitis typically involves small vessels, medium sized vasculitis can also occasionally be seen (Lanham et al, 1984). Lesions in the healing stages will show fibrosis with calcified nodules and a sparse or complete absence of inflammatory cells (Carlson & Chen, 2006;Chen et al, 2007). This is in contrast to PAN where the acute stage is marked by neutrophils and the healing stage by lymphocytes and histiocytes .…”