Granulomatous arthritis in crohn's disease

Al‐Hadidi, Samir; Khatib, Ghanim; Chhatwal, Prabhjeet; Khatib, Riad

doi:10.1002/art.1780270916

Cited by 15 publications

(10 citation statements)

References 7 publications

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“…Examples include sarcoidosis, CD, Whipple disease, primary biliary cirrhosis, infectious conditions such as tuberculosis and fungal infections, and idiopathic granulomatous disease of the liver (16–18). In CD, granulomas are found not only in the gastrointestinal tract but also in joints, kidneys, conjunctivae, pancreas, lymph nodes, and skin (19–25). The cause of most noninfectious granulomatous conditions remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Granuloma in Crohn's Disease

Ramzan

Leighton

Heigh

et al. 2002

Inflammatory Bowel Diseases

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Crohn's disease (CD) is diagnosed from information obtained clinically, pathologically, and radiologically. One important pathologic finding is a granuloma, which is helpful when a positive diagnosis of CD will affect treatment. Whether the presence of a granuloma has any clinical implication is not clear. We conducted a retrospective study to determine whether a granuloma found on a biopsy sample is associated with disease severity, fistulizing or perianal disease, frequent relapses, and extraintestinal manifestations. Eighty-two patients were identified who had a biopsy or bowel resection for CD between 1990 and 1994 at a tertiary referral center; 21 (25.6%) had a granuloma. This group was compared with a group of 61 patients without a granuloma. Forty-five percent were male (n = 37), mean age at diagnosis was 42.6 years (median, 39.5 years), mean disease duration at presentation was 8.8 years (median, 4.8 years), and mean follow-up duration was 2 years (range, 1 day to 10.2 years). No significant differences were demonstrated between the two groups by the Fisher exact test with regard to fistulizing or perianal disease, oral aphthous ulcers, disease severity, axial or peripheral arthralgia, episcleritis, anterior uveitis, erythema nodosum, or pyoderma gangrenosum.

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of Granuloma in Crohn's Disease

Ramzan

Leighton

Heigh

et al. 2002

Inflammatory Bowel Diseases

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“…The actual frequency of granuloma in CD synovium may be underestimated since very few histologic studies are available. There are at least two reports of synovial granulomata in CD synovium with one case where the histologic findings in the joint led the investigations to confirm the diagnosis of CD by colonoscopy [39,40]. Intestinal biopsies show nongranulomatous inflammation most of the time with granulomata at onset in about 25% of patients.…”

Section: Pathogenic Considerations and Conclusionmentioning

confidence: 99%

Blau syndrome and related genetic disorders causing childhood arthritis

Becker¹,

Rosé

2005

Curr Rheumatol Rep

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Blau Syndrome (BS) is an inheritable disorder characterized by granulomatous polyarthritis, panuveitis, and exanthema. It was described by Edward Blau in 1985, the same year in which Douglas Jabs reported a very similar family. Clinically indistinguishable from early onset sarcoidosis (EOS), both are now known to share a mutated form of caspase recruitment domain-15 (CARD 15), a protein involved in activation of nuclear factor kappa B which is in turn an up-regulator of pro-inflammatory cytokine transcription. An association between BS and EOS was suspected for years given the striking similarities of the core triad (arthritis-uveitis-dermatitis) and a common emerging pattern of systemic involvement. Hence, the familial form (BS) and the sporadic form (EOS) are almost certainly the same illness/defect, inherited in the first and acquired in the second as a result in most cases of a de novo mutation. Another form of granulomatous arthritis with uveitis, Crohn's disease, has also been associated with mutations in CARD 15 (albeit at a different domain) and despite similar phenotypes there are obvious differences including gut inflammation and pyoderma gangrenosum in Crohn's disease. This paper will review the clinical characteristics of these three disorders and their association with mutations in the CARD 15 gene.

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“…Comme dans notre série (n = 15, soit 50 % des cas), l'atteinte périphérique est la plus fréquemment retrouvée dans 8 à 40 % des cas de la littérature et ne s'accompagne habituellement d'aucune anomalie radiologique. Cependant, dans la littérature, quelques publications font état d'arthrites érosi-ves [28][29][30][31].…”

Section: Discussionunclassified