Granulomatous Cheilitis and Borrelia burgdorferi

Muellegger, Robert R.; Weger, Wolfgang; Zoechling, N; Kaddu, Steven; Soyer, H. Peter; Shabrawi‐Caelen, Laila El; Kerl, Helmut

doi:10.1001/archderm.136.12.1502

Cited by 41 publications

(16 citation statements)

References 25 publications

(29 reference statements)

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“…[1] Several theories have been suggested, including infection, genetic predisposition, and allergy. [2–6] The classic presentation of OFG is a nontender, recurrent labial swelling that eventually becomes persistent. [7] This swelling may affect one or both lips, causing lip hypertrophy.…”

Section: Introductionmentioning

confidence: 99%

Orofacial granulomatosis: A case report with review of literature

Rana

2012

J Indian Soc Periodontol

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Orofacial granulomatosis (OFG) encompasses conditions characterized by non-necrotizing granulomatous inflammation of the oral and maxillofacial region that present clinically as labial enlargement, perioral and/or mucosal swelling, oral ulcerations, and gingivitis. The unifying term “OFG” has been introduced to integrate the spectrum of various disorders, including Melkersson-Rosenthal syndrome and granulomatous cheilitis (which is sometimes considered to be a monosymptomatic form of Melkersson-Rosenthal syndrome), and has been shown to be associated with Crohn's disease, sarcoidosis, and infectious diseases such as tuberculosis. Although various etiological agents such as food substances, food additives, dental materials, and various microbiological agents have been implicated in the disease process, its precise pathogenesis is yet to be elucidated. Delayed type of hypersensitivity reaction appears to play a significant role, although the exact antigen inducing the immunological reaction varies in individual patients. However, evidence for the role of genetic predisposition to the disease is sparse. The underlying immunological mechanism appears to show some similarities between OFG and Crohn's disease, emphasizing the need for more comparative studies of the two entities. The aim of this article is to report a case of OFG, along with a detailed literature review of the facts and variations associated with its nomenclature, clinical presentation, and etiology. It also projects the challenges that a professional has to face in the diagnosis and treatment planning of such cases.

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Section: Introductionmentioning

confidence: 99%

Orofacial granulomatosis: A case report with review of literature

Rana

2012

J Indian Soc Periodontol

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“…7 There are reports that associate the pathogenesis of MC with odontogenic infection 4,9 and autoimmune mechanism. 9 Authors even mentioned that the episode of MC persists even after the infection has resolved in some patients. 4 Various food items including chocolate, food additives and cinnamon compounds have been implicated as possible etiologic agents; the elimination of these items from food have led to improvement in some patients.…”

Section: Discussionmentioning

confidence: 99%

Miescher’s cheilitis: A case report with literature review

Adhikari

Shah

2018

J Pathol Nep

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Miescher’s cheilitis is an inflammatory disorder characterized by chronic lip swelling due to granulomatous inflammation. It is rare disorder first described by Miescher in 1945. It is monosymptomatic form of Melkersson-Rosenthal syndrome. We report a case of Miescher’s cheilitis in a 59-year old lady presented with recurrent swelling and erythema of upper lip and submental area with no features of facial palsy and fissuring of tongue. Laboratory tests including serum complement C3, C4 and C1 esterase inhibitor functional were within normal limits. The biopsy from the upper lip revealed dermal edema, dilated lymphatic channels and multiple granulomas. After exclusion of other causes of orofacial granulomatosis, the diagnosis of Miescher’s cheilitis was made. Patient was treated with oral hydroxychloroquine and topical tacrolimus and mometasone cream with gradual improvement.

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“…Several theories have been postulated, including infection, genetic predisposition, and allergy [7–9]. A monoclonal lymphocytic expression, secondary to the chronic antigenic stimulation, cytokine production leading to granulomas formation, and a cell-mediated hypersensitivity reaction have also been suggested [10].…”

Section: Discussionmentioning

confidence: 99%

Granulomatous Cheilitis: Successful Treatment of Two Recalcitrant Cases with Combination Drug Therapy

Gupta¹,

Singh²

2014

Case Reports in Dermatological Medicine

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Granulomatous cheilitis is a rare, idiopathic, inflammatory disorder which usually affects young adults. It is characterized by persistent, diffuse, nontender, soft-to-firm swelling of one or both lips. Various treatment modalities have been suggested. In spite of the best treatment, recurrence of the disease is very common. We report two cases of granulomatous cheilitis treated with a combination of steroids, metronidazole, and minocycline with no signs of relapse at one-year follow-up.

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Granulomatous Cheilitis and Borrelia burgdorferi

Cited by 41 publications

References 25 publications

Orofacial granulomatosis: A case report with review of literature

Orofacial granulomatosis: A case report with review of literature

Miescher’s cheilitis: A case report with literature review

Granulomatous Cheilitis: Successful Treatment of Two Recalcitrant Cases with Combination Drug Therapy

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