Granulomatous Dermatitis in Common Variable Immunodeficiency With Functional T-Cell Defect

Mazzatenta, Carlo

doi:10.1001/archderm.142.6.783

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Granulomas In Immunodeficiency Disorders1

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Cited by 7 publications

(3 citation statements)

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“…687,688 In chronic granulomatous disease, despite the name, true granulomas are not common in cutaneous lesions. [698][699][700][701][702][703][704][705] This disease, which has multiple phenotypes, is the most commonly diagnosed primary immunodeficiency disease in adults, after selective IgA deficiency. 686,[689][690][691][692][693][694][695] Carriers of X-linked chronic granulomatous disease (OMIM 306400) may present with lupus erythematosus-like lesions.…”

Section: Granulomas In Immunodeficiency Disordersmentioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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Section: Granulomas In Immunodeficiency Disordersmentioning

confidence: 99%

The granulomatous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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“…GA and other cutaneous granulomas have been reported in the setting of T‐cell lymphoma 6,9 Several immunodeficiency states, notably common variable immune deficiency (CVID) 11 and HIV. 4 In the former, abnormal T‐cell function gives rise to macrophage activation.…”

Section: Reportmentioning

confidence: 99%

“…Several immunodeficiency states, notably common variable immune deficiency (CVID) 11 and HIV. 4 In the former, abnormal T‐cell function gives rise to macrophage activation.…”

Section: Reportmentioning

confidence: 99%

Widespread granuloma annulare and Hodgkin's disease

et al. 2008

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The presence of coexistent disseminated granuloma annulare (GA) and Hodgkin's disease (HD) is rare, with only six reported patients to date. We describe a patient with HD who had limited GA 2 years before the diagnosis of HD; widespread GA appeared after first-line treatment and heralded disease relapse. GA lesions showed hypermetabolic images on positron emission tomography, an interesting finding of unknown significance. We suggest a new pathophysiological mechanism for this association, i.e. that the reactive T-lymphocyte population in HD may contribute to granuloma formation through the secretion of cytokines and the subsequent upregulation of certain metalloproteinases. Diffuse cutaneous GA should raise the possibility of underlying systemic lymphoma or HD.

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