1985
DOI: 10.1016/0016-5085(85)90455-x
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Granulomatous enterocolitis induced in rats by purified bacterial cell wall fragments

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Cited by 166 publications
(82 citation statements)
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“…Alternatively, an NF-B-dependent secretion of downregulatory factors, such as transforming growth factor-␤, may be impaired (27,28). Consistent with this mechanism, PGN induces granulomatous enterocolitis, which resembles CD in genetically susceptible rats (29), and nf-b1-deficient mice exhibit chronic inflammation (30).…”
Section: Discussionmentioning
confidence: 90%
“…Alternatively, an NF-B-dependent secretion of downregulatory factors, such as transforming growth factor-␤, may be impaired (27,28). Consistent with this mechanism, PGN induces granulomatous enterocolitis, which resembles CD in genetically susceptible rats (29), and nf-b1-deficient mice exhibit chronic inflammation (30).…”
Section: Discussionmentioning
confidence: 90%
“…HLA-B27 transgenic rats colonized with a combination of E. contortum, P. productus, E. coli, S. faecum, and S. avium isolated from Crohn's disease patients (DESEP) unexpectedly had no significant increase in colitis or gastritis over that seen in GF rats, despite the fact that these specific strains were chosen because of their postulated role in IBD (2) and because they represent some of the most common aerobic and anaerobic constituents of the normal enteric flora (13). PG-PS from the first four of these bacterial strains induces arthritis after peritoneal injection (18,19), and intramurally-injected PG-PS from S. faecum causes chronic granulomatous enterocolitis (8). It is possible that increased serum antibodies to Eubacteria and Peptostreptococci in Crohn's disease patients (16) merely reflect enhanced mucosal absorption and/or heightened host immunoresponsiveness to these bacterial species, which are selectively increased in this disorder (15).…”
Section: Discussionmentioning
confidence: 99%
“…The relationship between luminal bacteria or bacterial products, colitis, and joint inflammation is well established (2,7,8,10,19,21,22,(51)(52)(53). Oligoarticular peripheral arthritis is associated with ulcerative colitis, Crohn's disease (especially of Figure 7.…”
Section: Discussionmentioning
confidence: 99%
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