Granulomatous hepatitis in Q fever

Pellegrin, M; Delsol, Georges; Auvergnat, Jean Charles; Familiadès, J; Faure, H; Guiu, Michel; Voigt, Jean J.

doi:10.1016/s0046-8177(80)80105-5

Cited by 106 publications

(37 citation statements)

References 12 publications

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“…Importantly, the inflammatory reaction associated with chronic Q fever endocarditis lacks well-formed granulomas. This observation suggests that patients with Q fever endocarditis could be unable to develop an effective cellular immune response against the bacterium, in contrast to that observed in the liver or bone marrow during acute Q fever [43][44][45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Cardiac Valves in Patients with Q Fever Endocarditis: Microbiological, Molecular, and Histologic Studies

et al. 2003

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The pathologic features of Q fever endocarditis, which is caused by Coxiella burnetii, were histologically evaluated in cardiac valves from 28 patients. We used quantitative image analysis to compare valvular fibrosis, calcifications, vegetations, inflammation, and vascularization due to Q fever endocarditis with that due to non-Q fever endocarditis and valvular degeneration. We also studied the presence of C. burnetii in valves by immunohistochemical analysis, culture, and polymerase chain reaction (PCR). Histologically, Q fever endocarditis was characterized by significant fibrosis and calcifications, slight inflammation and vascularization, and small or absent vegetations. Despite antibiotic treatment, non-statistically significant variations at the histologic level were observed. These pathologic features could be confused with noninfectious valvular degenerative damage. We found that the detection of C. burnetii in cardiac valves by immunohistochemical analysis, culture, and PCR decreased significantly only after 1 year of antibiotic treatment, which emphasizes the long persistence of this organism in valve tissues. Pathologic and immunohistochemical analyses may contribute to the diagnosis of Q fever endocarditis.

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Section: Discussionmentioning

confidence: 99%

Cardiac Valves in Patients with Q Fever Endocarditis: Microbiological, Molecular, and Histologic Studies

et al. 2003

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“…Coxiella burnetii (causative agent of Q fever) is associated with fibrin-ring granulomas; many Q fever granulomas are intermediate between epithelioid and fibrin-ring types. 24,25 Rickettsia conorii, the causative agent of boutonneuse fever and South African tick bite fever, may also cause granulomas. 26 Organisms are difficult to detect in the rickettsial illnesses, thus immunofluorescent stains and serologic studies may be very helpful.…”

Section: -23mentioning

confidence: 99%

Hepatic Granulomas: A Review With Emphasis on Infectious Causes

Lamps

2015

Archives of Pathology &Amp; Laboratory Medicine

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Context Many diseases that cause granulomas or granulomatous inflammation involve the liver. Some of these disease processes are intrinsic hepatic diseases, whereas others are disseminated systemic diseases that involve the liver as well as other organs. Objective To review the evaluation of granulomas in the liver with an emphasis on infectious causes, as well as the use of special stains, serologic studies, and molecular diagnostic techniques. Pertinent noninfectious causes of hepatic granulomas that are in the differential diagnosis are also discussed. Data Sources Literature review and cases acquired during years of practice. Conclusions A wide variety of infectious and noninfectious entities cause hepatic granulomas.

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“…This fibrin deposition can also be scattered among epithelioid cells. 46 Boutonneuse fever and South African tick bite fever that are caused by Rickettsia conorii can also cause hepatic granulomas. In these cases, the diagnosis is based on serology.…”

Section: Bovismentioning

confidence: 99%

Granulomatous liver diseases: A review

Coash

Forouhar

et al. 2012

Journal of the Formosan Medical Association

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Granulomas that consist of focal accumulations of macrophages are commonly found in the liver due to stimulation of the immune system by a number of agents. Manifestations are variable depending on whether the underlying cause is a systemic disease or a primary hepatic granulomatous reaction. This article describes the common causes, presentation, histopathology, and manifestations of granulomatous diseases as well as various diagnostic and management strategies.

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Granulomatous hepatitis in Q fever

Cited by 106 publications

References 12 publications

Cardiac Valves in Patients with Q Fever Endocarditis: Microbiological, Molecular, and Histologic Studies

Cardiac Valves in Patients with Q Fever Endocarditis: Microbiological, Molecular, and Histologic Studies

Hepatic Granulomas: A Review With Emphasis on Infectious Causes

Granulomatous liver diseases: A review

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