Granulomatous inflammation in ginbuna crucian carp Carassius auratus langsdorfii against Mycobacterium gordonae

Kato, Go; Kakazu, Taichi; Yamada, M.; Lau, Lik-Ming; Nakajima, Kazue; Sato, Shoh; Nakanishi, Teruyuki; Sano, Motohiko

doi:10.1016/j.dci.2018.10.009

Cited by 11 publications

(3 citation statements)

References 39 publications

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“…Similarly, Jung et al ( 2020a , b ) investigated the cellular immune response of CD4-1 + and CD4-2 + T cells after infection with viral hemorrhagic septicemia virus (VHSV) and nervous necrosis virus (NNV) in flounder. A polyclonal antibody anti-CD4-1 was also developed in ginbuna crucian carp ( Carassius auratus langsdorfii ) to analyse the immunity of CD4-1 + cell in the granulomatous inflammation against mycobacterial infections (Kato et al 2019 ).…”

Section: Diversity Of Cd4 Molecules and Cd4 + T Ly...mentioning

confidence: 99%

Cluster of differentiation antigens: essential roles in the identification of teleost fish T lymphocytes

Tian

Xing

Tang

et al. 2022

Mar Life Sci Technol

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Cluster of differentiation (CD) antigens are cell surface molecules expressed on leukocytes and other cells associated with the immune system. Antibodies that react with CD antigens are known to be one of the most essential tools for identifying leukocyte subpopulations. T lymphocytes, as an important population of leukocytes, play essential roles in the adaptive immune system. Many of the CD antigens expressed on T lymphocytes are used as surface markers for T lymphocyte classification, including CD3, CD4 and CD8 molecules. In this review, we summarize the recent advances in the identification of CD molecules on T lymphocytes in teleosts, with emphasis on the functions of CD markers in the classification of T lymphocyte subsets. We notice that genes encoding CD3, co-receptors CD4 and CD8 have been cloned in several fish species and antibodies have been developed to study protein expression in morphological and functional contexts. T lymphocytes can be divided into CD4+ and CD8+ cells discriminated by the expression of CD4 and CD8 molecules in teleost, which are functionally similar to mammalian helper T cells (Th) and cytotoxic T cells (Tc), respectively. Further studies are still needed on the particular characteristics of teleost T cell repertoires and adaptive responses, and results will facilitate the health management and development of vaccines for fish.

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Section: Diversity Of Cd4 Molecules and Cd4 + T Ly...mentioning

confidence: 99%

Cluster of differentiation antigens: essential roles in the identification of teleost fish T lymphocytes

Tian

Xing

Tang

et al. 2022

Mar Life Sci Technol

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“…The marginal lymphocytes were positive for CD4-1, and the IFNc-producing cells surrounded the mycobacterial cell-laden phagocytes. CD4-1+ cells and IFNc2 played important roles in the granulomatous inflammationKato et al (2019) Nocardia seriolaeSpotted butterfish (Scatophagus argus, Linn)Enlargement of spleen, kidney and liver with white nodules varying in size. The pathogen caused systemic granulomasWang et al (2014) Snubnose pompano (Trachinotus blochii)…”

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confidence: 99%

Granulomatosis in fish aquaculture: a mini review

Martínez‐Lara

Martínez‐Porchas

Gollas‐Galván

et al. 2020

Reviews in Aquaculture

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Bacterial infections represent the greatest threat for fish culture, especially those causing granulomatous processes. Although there are experimental models used to elucidate the mechanisms of pathogenicity in granulomatous processes, most of these aimed to understand the infection in superior vertebrates like humans; therefore, there is still an urgent need to expand the number of infection models focused on aquaculture. Granulomatous infections are difficult to detect in early stages due to the lack of clinical signs and because these clinical signs have a great similarity to those generated by other pathogenic bacteria. Besides, there is no evidence or reports of granulomatous co-infections in aquaculture environments which is a plausible scenario either in culture systems or in the wild environment; co-infections could interfere with a correct diagnosis of any granulomatous disease, as reported for granulomatous infections in terrestrial species. This revision aims to highlight the state of the art in the knowledge of pathogenic bacteria associated with granulomatosis in fish aquaculture as well as analysing this information.

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“…(Rousselet et al, 2018), Mycobacterium spp. (Madigan et al, 2017;Johansen et al, 2018;Kato et al, 2019), and Nocardia sp. (Wang et al, 2014).…”

Section: Gross Pathology and Histopathology Analysismentioning

confidence: 99%

Identification, characterization and pathogenicity of aeromonas schubertii isolated from diseased striped snakehead fish (Channa Striata)

Budiyansah

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Striped snakehead fish (Channa striata) is one of the popular cultivated fish in Thailand. However, it is inevitable to be susceptible to abundant pathogens, especially Aeromonas schubertii. In July 2020, an unknown outbreak was occurred on striped snakehead fish nursery farm in Nakhon Pathom province, Thailand. Suspected six isolates were A. schubertii yielded from the fish as the main causative agent. This research aimed to characterize and examine pathogenicity of A. schubertii isolated from diseased striped snakehead fish.� Characterization was performed based on combination of biochemical assay, PCR and DNA sequencing (based on 16S rRNA and gyrB), and MALDI-TOF MS. The results showed the A. schubertii isolates can be distinguished from other bacterial pathogens by its biochemical characteristics, DNA fingerprints (16S rRNA and gyrB), and protein mass fingerprints. The experimental challenge of A. schubertii, using intra-peritoneal (IP) injection on C. striata, showed 80% mortality on high dose (1.2x108) and median lethal dose (LD50) of 3.9x105. A significant manifestation of skin ulceration, internal organ hemorrhage and white nodules on the fish internal organs (liver, kid-ney, and spleen) was progressively seen on 7-, 14-, and 21-days of post injection (dpi). The white nodules significantly appeared at the liver, spleen, and kidney, respectively. Likewise, granulomas, melano-macrophage centers (MMCs) and necrotic cells were also observed in histopathology analysis. Moreover, it was discovered that white nodules on kidney and spleen were strongly correlated with granulomas observed on kidney and spleen histopathology.

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Granulomatous inflammation in ginbuna crucian carp Carassius auratus langsdorfii against Mycobacterium gordonae

Cited by 11 publications

References 39 publications

Cluster of differentiation antigens: essential roles in the identification of teleost fish T lymphocytes

Cluster of differentiation antigens: essential roles in the identification of teleost fish T lymphocytes

Granulomatosis in fish aquaculture: a mini review

Identification, characterization and pathogenicity of aeromonas schubertii isolated from diseased striped snakehead fish (Channa Striata)

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