Granulomatous inflammation in juvenile idiopathic arthritis–associated uveitis

Keenan, Jeremy D.; Tessler, Howard H.; Goldstein, Debra A.

doi:10.1016/j.jaapos.2008.05.012

Cited by 32 publications

(20 citation statements)

References 19 publications

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“…However, other inflammatory conditions that show no or weak CARD15 association, such as ulcerative colitis [9], rheumatoid arthritis, ankylosing spondylitis, type I diabetes or systemic lupus erythematosus [5] lack this clinical feature. We further report here on another inflammatory condition (idiopathic uveitis) that, in most instances (and definitely in none of our patients), is not associated to granuloma formation [4,8] and that also fails to show any association with this gene, whether we analyze the NBD domain (as in the present work) or the LRR region of the molecule (as in a previous work from our group [14]). Some other pathologies, such as malignancies [5] or graft versus host (GvH) disease in stem cell transplantation [3] have been effectively linked to CARD15 mutations and yet none of them is granulomatous.…”

Section: Discussionsupporting

confidence: 49%

Blau Syndrome-Related CARD15/NOD2 Mutations Are Not Linked to Idiopathic Uveitis in Spanish Patients

et al. 2009

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Abstract. Uveitis is a clinical feature of the Blau syndrome, a disease linked to CARD15 (also referred to as NOD2) mutations. Three main mutations in this gene (R334W, R334Q and L469F) have been reported as Blau syndrome risk factors, a disease that manifests uveitis as one of its clinical features. However, little is known on the involvement of this gene in idiopathic uveitis. We thus sought to determine the frequency of these Blau-related CARD15 mutations in a cohort of Spanish patients with idiopathic uveitis. To this aim, 110 patients with idiopathic uveitis, followed at the Department of Ophtalmology of a tertiary hospital (Hospital Universitario Alcalá de Henares, Madrid. Spain) were enrolled. As a control population, 104 healthy subjects were used. DNA was extracted from blood samples and the Blau-related CARD15 mutations were analysed either by PCR-RFLP or direct DNA sequencing. None of the mutations studied was found in any of the individuals tested, whether diseased or healthy. It seems thus that Blau syndrome-related CARD15 mutations are not involved in idiopathic uveitis, a finding which allows us to suggest that the genetic aetiology of the idiopathic uveitis or the Blau-associated uveitis is different.

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Section: Discussionsupporting

confidence: 49%

Blau Syndrome-Related CARD15/NOD2 Mutations Are Not Linked to Idiopathic Uveitis in Spanish Patients

et al. 2009

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“…Although nongranulomatous uveitis is typical for JIA, granulomatous features may be seen, especially in a black population. 16 In the vast majority of cases, the uveitis is bilateral, either simultaneously or within a few months of each other. Anterior chamber cells of mild to moderate degree (1þ to 3þ) are present during periods of active inflammation and may be associated with nongranulomatous keratic precipitates localized to the inferior half of the cornea and numerous fine endothelial inflammatory deposits.…”

mentioning

confidence: 99%

Juvenile Idiopathic Arthritis-Associated Uveitis: Clinical Features and Complications, Risk Factors for Severe Course, and Visual Outcome

Vitale

Graham

Boer

2013

Ocular Immunology and Inflammation

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Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and the most prevalent systemic disorder in children with uveitis. The risk of developing uveitis is the greatest among patients with oligoarticular onset of disease. Clinical features of JIA-associated uveitis (JIAU) are nongranulomatous inflammation, anterior in location, insidious at onset, chronic course, and frequently asymptomatic in the absence of ocular structural complications. Uveitis in JIA can worsen over time with many sight-threatening complications, such as band keratopathy in the visual axis, posterior synechiae, cataract, secondary glaucoma, macular edema, hypotony, epiretinal membrane, and optic nerve edema. Different studies have pointed out that several factors are associated with poor prognosis, including young age at onset, male gender, short interval between diagnosis of arthritis and uveitis, severity of uveitis at onset, and antinuclear antibody (ANA) positivity. Although JIA associated-uveitis is still a serious blinding disease, we are at least able to identify the high-risk group.

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“…45,68 In a recent study, granulomatous uveitis in children with JIA was found to be more common than previously reported, particularly in African Americans and ANA-positive children. 69 Although the inflammation is centered in the anterior chamber, cells may be seen in the anterior vitreous as well (iridocyclitis). Cystoid macular edema may also develop, but retinitis and choroiditis do not occur.…”

Section: ' Clinical Presentationmentioning

confidence: 99%