Granulomatous inflammation of the liver in mice with gadolinium chloride-blocked Kupffer cells

Liver resistance to toxic effects of CCl4 under conditions of gadolinium chloride depression of Kupffer cells

“…It is important to note that the dynamics of injury, inflammatory infiltration, and liver recovery after GdCI 3 blockade were similar to the time course of KC repopulation, i.e. with the increase in the number of macrophages and their clearing capacity [4]. Aggravation of liver damage can be attributed to a decrease in the number of functionally active KC and their hepatoprotective potential depending on secretion of interleukin-1, tumor necrosis factor, etc.…”

“…inhibition of growth factors production [7]. Sharp suppression of inflammatory infiltration in mice treated with GdCI 3 can be due to reduced hemopoiesis-stimulating activity of KC [4]. At the same time, not only activated KC, but also macrophages potentiate hepatocyte regeneration [5].…”