2021
DOI: 10.1183/23120541.00467-2021
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Granulomatous–lymphocytic interstitial lung disease: an international research prioritisation

Abstract: Granulomatous–lymphocytic interstitial lung disease (GLILD) has been defined as “a distinct clinico-radio-pathological ILD [interstitial lung disease] occurring in patients with CVID [common variable immunodeficiency disorders], associated with a lymphocytic infiltrate and/or granuloma in the lung, and in whom other conditions have been considered and where possible excluded… usually seen in the context of multisystem granulomatous/inflammatory involvement” [1]. The immune and inflammatory complications of CVI… Show more

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Cited by 7 publications
(3 citation statements)
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“…The superiority of first-line treatment over watchful waiting was one of the top-ranked questions in a recent research prioritisation exercise in GLILD [ 14 ]. We are the first complete, single-centre cohort reporting the change in lung function over time for GLILD patients who were not receiving immunosuppression treatment.…”
Section: Discussionmentioning
confidence: 99%
“…The superiority of first-line treatment over watchful waiting was one of the top-ranked questions in a recent research prioritisation exercise in GLILD [ 14 ]. We are the first complete, single-centre cohort reporting the change in lung function over time for GLILD patients who were not receiving immunosuppression treatment.…”
Section: Discussionmentioning
confidence: 99%
“…CVID-ILDs share clinical and histological characteristics with other conditions, and there is currently no single consensus on the diagnostic criteria for CVID-ILD. The understanding of pathogenesis is limited, and significant gaps in knowledge about diagnosis and management remain ( 5 , 7 ). No evidence-based guideline for diagnosis or treatment is currently available, and management generally relies on clinicians’ expert opinions ( 7 , 8 ).…”
Section: Introductionmentioning
confidence: 99%
“…The understanding of pathogenesis is limited, and significant gaps in knowledge about diagnosis and management remain ( 5 , 7 ). No evidence-based guideline for diagnosis or treatment is currently available, and management generally relies on clinicians’ expert opinions ( 7 , 8 ).…”
Section: Introductionmentioning
confidence: 99%