Granulomatous mastitis: changing clinical and imaging features with image-guided biopsy correlation

Handa, Priyanka; Leibman, A. Jill; Sun, Derek; Abadi, Maria; Goldberg, A.

doi:10.1007/s00330-014-3273-z

Cited by 15 publications

(23 citation statements)

References 17 publications

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“…The most frequent US findings were multiple irregular hypoechoic masses and collections connected to each other with finger-like tubular hypoechoic structures (83.3%), similar to those reported in previous literature [2,8,[12][13][14][15][16]. Ill-defined heterogeneous hypoechoic pattern compared with surrounding normal breast parenchyma was also another less common finding [17]. We noted this rare finding in 2 of 30 cases (6.6%).…”

Section: Treatmentsupporting

confidence: 86%

“…As reported in previous literature [9,15,17], there is increased vascularisation in the vicinity of the IGM in Doppler US. However, the number of series in the literature are small and only 40% of our cases (12 of 30) had available Doppler US findings for evaluation.…”

Section: Treatmentsupporting

confidence: 79%

“…Hypointense mass lesion with irregular margin on T2-w images with slow contrast enhancement on post-contrast T1-w images Parenchymal distortion was not reported before [2,8,12] and microcalcifications was reported in only one study [17].…”

Section: (80)mentioning

confidence: 90%

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Radiologic findings of idiopathic granulomatous mastitis

et al. 2015

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Aim: To describe the radiological findings of idiopathic granulomatous mastitis (IGM). Material and methods: Radiologic findings of 30 women with histopathological diagnosis of IGM were retrospectively evaluated. All had breast feeding history. All the patients had ultrasonography (US), with 12 of them having additional Doppler US. Of 30 patients, 11 had mammography (MG) and 5 MRI. Results: US showed multiple irregular hypoechoic masses and collection areas with tubular connections in 25 of 30. The collection area with low-level internal echoes but without tubular connections, suggesting an abscess were seen in 2 of 30 (6.6%); a hypoechoic mass with an indistinct border in 2 of 30 (6.6%); multiple milimetric hypoechoic nodular masses in 1 of 30 (3.3%). On MG, normal findings were noted in 5 (45.4%); focal asymmetric density in 4 (36.4%), parenchymal distortion in 1 (9%) and diffuse asymmetric opacity with trabecular thickening in 1 (9%) of 30 patients. On MRI, segmental T2 hyperintensity with contrast-enhancement on T1 were seen in 4 of 5 (80%). An enhancing T2 hypointense mass with irregular margin was present in 1 of 5 (20%). Time-signal intensity curve of lesions showed slow enhancement in 1 and moderate in 4 of 5 patients. Conclusions: In IGM, MG findings were nonspecific. In US, multiple irregular hypoechoic masses and collections with tubular connections with fingerlike aspects, and fistulae formation to the skin in patients with breastfeeding history suggested IGM rather than carcinoma. Due to the limited number of patients, no conclusion was reached regarding MRI of IGM.

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Section: Treatmentsupporting

confidence: 86%

Section: Treatmentsupporting

confidence: 79%

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Radiologic findings of idiopathic granulomatous mastitis

et al. 2015

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“…GLM was generally associated with clinical symptom of breast lump, abscess, inflammation, and mammary duct fistula or sinus in this study, and this is consistent with the literature [13]; the most common clinical presentation was breast lump with or without skin change and pain, and the most common ultrasonographic finding was a large irregular hypoechoic mass. In the absence of specific radiologic findings, the diagnosis of GLM is based on histopathologic findings.…”

Section: Discussionsupporting

confidence: 80%

Granulomatous Lobular Mastitis: Antituberculous Treatment and Outcome in 22 Patients

et al. 2018

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Background: Granulomatous lobular mastitis (GLM) is a rare chronic inflammatory condition of the breast. The purpose of this study was to describe antituberculous treatment of GLM and the long-term follow-up outcome. Methods: This retrospective study included 22 patients who had been histopathologically diagnosed with GLM at the Second Hospital of Shandong University from January 2011 to March 2015. Clinical characteristics, ultrasonography and mammography findings, laboratory tests, treatment regimens, follow-up information, and recurrences were recorded. Results: All patients were female with a median age of 29 (range 23-44) years. The most common symptom was a breast mass with or without pain. Large irregular hypoechoic masses could be found in the breast ultrasounds of 13 patients. All patients received triple antituberculous therapy. During a median follow-up period of 40 months, 3 patients were lost to follow-up; of the remaining 19 patients, 18 achieved clinical complete remission and no recurrences were observed. Conclusion: GLM is an unusual benign breast condition that mimics breast carcinoma in its clinical and imaging presentation. Antituberculous therapy seems to be an effective alternative option in the treatment of GLM.

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“…The characteristic of reviewed articles is summarized in Table (). The total number of articles was 70, 59 in group A and 11 in group B.…”

Section: Resultsmentioning

confidence: 99%

Idiopathic granulomatous mastitis: A systematic review of 3060 patients

et al. 2019

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Idiopathic granulomatous mastitis is a rare benign breast disease. A systematic review was designed. Clinical and therapeutic characteristics were analyzed. Human Development Index (HDI) was used to define two groups of study: group A (very high and high HDI) and group B (medium and low HDI). Corticosteroid therapy was done in 69% group A and 78% group B. Surgery was done in 63% in group A and 83% in group B. Antibiotics were used in 68% group A and 88% group B. There is no consensus about optimal treatment for granulomatous mastitis.

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Granulomatous mastitis: changing clinical and imaging features with image-guided biopsy correlation

Abstract: • Characterizes radiographic appearance of granulomatous mastitis in postmenopausal or asymptomatic patients. • Granulomatous mastitis can present exclusively as calcifications on mammography. • The diagnosis of granulomatous mastitis is made by image-guided biopsy techniques.

Cited by 15 publications

References 17 publications

Radiologic findings of idiopathic granulomatous mastitis

Radiologic findings of idiopathic granulomatous mastitis

Granulomatous Lobular Mastitis: Antituberculous Treatment and Outcome in 22 Patients

Idiopathic granulomatous mastitis: A systematic review of 3060 patients

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