Granulomatous mastitis diagnosed and followed up by fine-needle aspiration cytology, and successfully treated by corticosteroid therapy: Report of a case

Sato, Norihiro; Yamashita, Hiroyuki; Kozaki, Naoto; Watanabe, Yoshifumi; Ohtsuka, Takao; Kuroki, Shin-Ichiro; Nakafusa, Yuji; Ota, Masayuki; Chijiiwa, Kazuo; Tanaka, Masao

doi:10.1007/bf00312095

Cited by 45 publications

(50 citation statements)

References 4 publications

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“…One third of the patients with granulomatous mastitis have a history of oral contraceptive use in some publications (7). Two (17%) of our cases were on oral contraceptives at the time of diagnosis (4,8,22,(25)(26)(27). The infectious agents were implicated in the etiology of GLM, but they have not been isolated and proven so far (9).…”

Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 80%

“…We believe the steroid regimen has the advantage of a low rate of side effects. Despite GLM has no optimal management, there are publications of recent studies reporting that large surgical excision following or without a steroid therapy is a favorable treatment of choice (2,9,23,26,27,41). Asoglu et al (23) reported that, among 18 cases who had undergone large local excision, recurrence was observed only in one case during 36 months of follow-up, who was treated with re-excision.…”

Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 99%

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A Challenging Entity in the Differential Diagnosis of Breast Cancer: A Retrospective Analysis of 17 Cases With Granulomatous Lobular Mastitis

Eser¹,

Kaptanoğlu²,

Kement³

et al. 2013

J Breasth Health

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Results: All the cases were women of childbearing age, who had given birth and breastfed at least once. The most common causes for admission were; breast mass in 12 patients (70.6%) and pain in 12 (70.6%) cases. Five (29.4%) cases developed a fistula and four (23.5%) had abscess requiring drainage. Mammography was used for 10 (58.8%) cases, 12 (70.6%) were examined by MRI and all the patients were evaluated with ultrasound. Five (29.4%) cases were suspicious for malignancy prior to biopsies. Diagnoses of sixteen (94.1%) cases were established with tru-cut biopsy. Fourteen (82.3%) cases underwent wide local excision (WLE) following antibiotic therapy and/or drainage and 3 (17.6%) cases with diffuse disease also underwent wide local excision following therapy with antibiotics and/or drainage and steroids (prednisolone 32 mg bid). Complete remission was observed in one patient with diffuse disease who was referred to our clinic with excisional biopsy after steroid therapy (prednisolone 32 mg bid). Relapse developed in two (11.7%) cases in the end of thirty-six months of median follow-up. Both patients were treated with steroids (prednisolone 32 mg bid). Sonuç: GLM zor tanı konulabilen ve yaygın kabul görmüş bir tedavisi olmayan selim bir meme hastalığıdır. Geniş local eksizyon uygun olgularda tek başına, yaygın tutulumu olan olgularda ise steroid tedavisi sonrası başarı ile uygulanabilir. Conclusion

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Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 80%

Section: Figure 2 Mammographic Imaging Of the Breast Before Treatmenmentioning

confidence: 99%

A Challenging Entity in the Differential Diagnosis of Breast Cancer: A Retrospective Analysis of 17 Cases With Granulomatous Lobular Mastitis

Eser¹,

Kaptanoğlu²,

Kement³

et al. 2013

J Breasth Health

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“…Although wide excision of the mass was traditionally performed in the past, this was followed by a high rate of recurrence, skin ulceration, abscess formation, fistulae formation, and wound infection [1,4,9]. Corticosteroid therapy is effective in decreasing the granulomatous mass in this disease [4,10,11]. Many of the previous reports on IGM have focused on the histological and radiological features; however, few reports have been published on the progress of this disease when treated with corticosteroids [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Can Steroids plus Surgery Become a First-Line Treatment of Idiopathic Granulomatous Mastitis?

et al. 2014

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Background: The aim of this study is to compare the clinical course of idiopathic granulomatous mastitis (IGM) treated with low-dose oral corticosteroid therapy alone as opposed to treatment with low-dose corticosteroid therapy followed by surgery. Patients and Methods: 37 patients were treated with an approach that consisted of methylprednisolone at a dose of 0.5 mg/kg/day followed by wide excision, and 23 patients were treated with an approach that consisted only of methylprednisolone. The treatment efficacy was compared between the two groups. Results: Clinical and radiological regression was reported in all patients with steroid therapy, and the regression rate had a median of 75% (25-100%). No recurrence was observed in patients who were treated with wide surgical excision after steroid therapy during the median follow-up period of 38 (22-78) months. The control group of 23 patients was treated only with steroid therapy, and 7 (30%) of these patients experienced recurrence in the follow-up period (p < 0.001). Conclusions: Steroid therapy was effective in the treatment of IGM by reducing the lesion size and extent. With regard to the current treatment options available for IGM, surgical excision after steroid therapy seems the better treatment option compared to steroid therapy without surgical excision. This treatment sequence reduces the rate of recurrence.

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“…Medical treatment with corticosteroids provides significant regression of the inflammatory disease allowing more conservative surgery. 12 Consecutive surgical excision of the remaining lesions with good cosmetic results provides definitive treatment and reduces the risk of recurrence. 8,11 …”

Section: Resultsmentioning

confidence: 99%

Critical Review of Granulomatous Mastitis

Govindasamy¹,

Rajamanickam²,

Chandramohan³

2016

jemds

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BACKGROUNDThe clinical manifestations, imaging and pathological findings though typical are closely mimicking other specific granulomatous types like tuberculosis; mycotic the treatment for this condition needs to be carefully planned in the initial stage itself. This will resolve the psychological issues and prevent recurrence. The study includes 30 cases of granulomatous mastitis belonging to varying age groups, social status, parity and menopausal status. The diagnostic workup is mainly in the form of imaging and histopathological in close correlation with clinical findings, helped us to treat the patients effectively. The treatment modalities offered, results and followup are tabulated.The purpose of this study is to present the author's experience by their critical clinical analysis based on aetiopathological and imaging modalities and to formulate effective treatment modalities in granulomatous mastitis.

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Granulomatous mastitis diagnosed and followed up by fine-needle aspiration cytology, and successfully treated by corticosteroid therapy: Report of a case

Cited by 45 publications

References 4 publications

A Challenging Entity in the Differential Diagnosis of Breast Cancer: A Retrospective Analysis of 17 Cases With Granulomatous Lobular Mastitis

A Challenging Entity in the Differential Diagnosis of Breast Cancer: A Retrospective Analysis of 17 Cases With Granulomatous Lobular Mastitis

Can Steroids plus Surgery Become a First-Line Treatment of Idiopathic Granulomatous Mastitis?

Critical Review of Granulomatous Mastitis

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