Granulomatous (pseudotumoral) iridociclitis associated with leishmaniasis in a cat

Hervás, J.; Lara, F. Chacón-Manrique de; López, José García; Moreno, A.; Guerrero, M. Morono; Gómez-Villamandos, J.C.

doi:10.1136/vr.149.20.624

Cited by 38 publications

(54 citation statements)

References 7 publications

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“…Indeed, some of them could be age-related (cat of 13 years), but we cannot exclude a general response of the organism toward the widespread presence of the protozoan in the cat organism (host immune response). For the most part, the non-specificity of the symptoms and the rareness of the infection make the diagnosis of feline leishmaniosis difficult because of the confusion with other diseases or with symptoms of aging (Hervas et al, 1999;Hervas et al, 2001). So far, we are not able to assess the occurrence of an immunodeficiency that could have led to infection by Leishmania infantum.…”

Section: Discussionmentioning

confidence: 99%

Leishmaniosis due toLeishmania infantumin a FIV and FeIV positive cat with a squamous cell carcinoma diagnosed with histological, serological and isoenzymatic methods

Grevot

Hugues²,

Marty³

et al. 2005

Parasite

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Section: Discussionmentioning

confidence: 99%

Leishmaniosis due toLeishmania infantumin a FIV and FeIV positive cat with a squamous cell carcinoma diagnosed with histological, serological and isoenzymatic methods

Grevot

Hugues²,

Marty³

et al. 2005

Parasite

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“…Leishmania organisms and associated inflammation were found in different ocular tissues, accounting for ocular clinical signs described with canine VL [39]. There have been three cases of feline ocular leishmaniasis reported [22,26]. In the most recent case, initial ophthalmic examination revealed bilateral deep stromal corneal ulcers, exudative panuveitis and secondary glaucoma.…”

Section: Endo-ocular Parasitismmentioning

confidence: 99%

Neurologic Manifestations ofLeishmania spp.Infection

Petersen¹,

Greenlee²

2011

J. Neuroparasitolog.

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When listing common clinical signs of the spectra of Leishmania-derived diseases, neurologic malfunctions are not commonly included. Despite this, there are multiple reported instances both in human and veterinary medicine where neurologic manifestations, whether central or peripheral, are described. In this review, we describe neurologic manifestations seen during infection with Leishmania spp. with some discussion of the implicit effect of inflammation on the blood brain barrier in both medical and veterinary cases. Taken together, the material discussed here suggests that in patients from Leishmania-endemic areas, when observing neurologic symptoms, causation secondary to infection with Leishmania spp. should be highly considered.

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“…Μέχρι σήμερα δεν έχει διαπιστωθεί προδιάθεση ως προς την ηλικία (2-14 ετών), το φύλο ή τη φυλή (τα περισσότερα περιστατικά αφορούσαν στην κοινή ευρωπαϊκή φυλή), με τις περισσότερες ασθενείς γάτες να έχουν πρόσβαση σε εξωτερικό περιβάλλον ή να ζουν συνέχεια έξω από το σπίτι (Herväs et al 1999, Herväs et al 2001, Pennisi 2002, Poli et al 2002, Pennisi et al 2004, Grevot et al 2005, Marcos et al 2009, Navarro et al 2010). …”

Section: παθογενεια καινικη εικονα και εργαστηριακα ευρηματαunclassified

“…Οι συχνότερες δερματικές αλλοιώσεις είναι τα έλκη (25-33%) και τα οζίδια (40%) (Pennisi . Τα έλκη εντο πίζονται στην κεφαλή (βλεννογονοδερματικά όρια, επιρρίνιο, πρόσωπο, πτερύγια των αυτιών) και λιγό τερο συχνά στις οστέινες προεξοχές των άκρων και στο θώρακα (Herväs et al 1999, Herväs et al 2001, Perniisi 2002, Grevot et al 2005. Οι αλλοιώσεις αυτές συνήθως είναι μονήρεις, μερικές φορές συνοδεύονται από γενικευμένη αλωπεκία και εφελκιδοποίηση, ενώ στην ιστοπαθολογική τους εξέταση μπορεί να διαπι στωθεί διάχυτη κοκκιωματώδης φλεγμονή και μέτριος αριθμός παρασίτων (Perniisi 2002, Navarro et al 2010.…”

Section: παθογενεια καινικη εικονα και εργαστηριακα ευρηματαunclassified

“…Στα οφθαλμικά συμπτώματα, που μπορεί να αφο ρούν στον ένα ή/και στους δύο οφθαλμούς, περιλαμ βάνονται η επιπεφυκίτιδα, η κερατίτιδα, η ελκώδης κερατίτιδα, η πρόσθια και οπίσθια ραγοειδίτιδα, η χοριοαμφιβληστροειδίτιδα και η πανοφθαλμίτιδα (Herväs et al 2001, Perniisi 2002, Perniisi et al 2004, Leiva et al 2005, Ayllon et al 2008, Navarro et al 2010. Στην ιστοπαθολογική εξέταση των προσβε βλημένων οφθαλμικών ιστών διαπιστώνεται διάχυτη κοκκιωματώδης φλεγμονή που συνοδεύεται από μεγά λο παρασιτικό φορτίο (Navarro et al 2010).…”

Section: παθογενεια καινικη εικονα και εργαστηριακα ευρηματαunclassified

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Feline leishmaniosis due to Leishmania infantum (syn. L. chagasi)

Chatzis

Saridomichelakis

Koutinas

2018

J Hellenic Vet Med Soc

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From the beginning of the 20th century, feline infections by at least eight different Leishmania species have been sporadically reported, worldwide. In the Mediterranean countries, feline infection imposed by L. infantum, the aetiological agent of canine leishmaniosis and human visceral and cutaneous leishmaniasis, is of particular importance, because cats may represent a "secondary reservoir" of the parasite in the nature. Although the prevalence of the infection may be as high as 60%, most infected cats are resistant and remain asymptomatic, while only occasionally, they may present cutaneous and/or ocular lesions, and perhaps systemic clinical signs. In feline leishmaniosis, ulcers and nodules, usually localized at mucocutaneous junctions, planum nasale, face and ear pinnae, constitute the mainstream of cutaneous lesions. In a small number of cases, exfoliative dermatitis and pododermatitis have been noted, whereas a cause-and-effect relationship, between feline leishmaniosis and the presence of papules, crusts and generalized alopecia remains speculative. Ocular lesions, such as those associated with conjunctivitis, (ulcerative) keratitis, posterior or anterior uveitis, chorioretinitis and panopthalmitis are relatively common. The only systemic signs that have been constantly associated with feline leishmaniosis are peripheral lymphadenomegaly, splenomegaly, hepatomegaly and chronic nephritis that may lead to chronic renal failure. The most consistent laboratory abnormality is hyperglobulinaemia that is usually polyclonal. Feline leishmaniosis can co-exist with various other infectious and non-infectious diseases that may alter its clinical picture and/or influence the immunological response of the infected cat. Diagnosis is usually based on the results of cytology,histopathology, immunohistochemistry, culture, serology and polymerase chain reaction (PCR). Apart from the advantages and limitations inherent to each of these methods, their diagnostic value depends on many factors, such as the biological sample being used, the reagents and the particular technique employed. Leishmania amastigotes can be detected by applying bone marrow, lymph node, spleen, cutaneous and ocular cytology, histopathology, and/or immunohistochemistry, which are 100% specific. Serology may underestimate or even overestimate the frequency of the infection in the endemic areas, depending on the methodology and the cut-off value, whereas PCR, that can be performed on the tissues mentioned before, plus the peripheral blood may be a better option for epidemiological studies. Although a uniformly effective treatment for symptomatic cats has not been established yet, long-term allopurinol administration, along with the management of any concurrent diseases, is the only treatment to suggest at moment.

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Granulomatous (pseudotumoral) iridociclitis associated with leishmaniasis in a cat

Cited by 38 publications

References 7 publications

Leishmaniosis due toLeishmania infantumin a FIV and FeIV positive cat with a squamous cell carcinoma diagnosed with histological, serological and isoenzymatic methods

Leishmaniosis due toLeishmania infantumin a FIV and FeIV positive cat with a squamous cell carcinoma diagnosed with histological, serological and isoenzymatic methods

Neurologic Manifestations ofLeishmania spp.Infection

Feline leishmaniosis due to Leishmania infantum (syn. L. chagasi)

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