Granulomatous Slack Skin: Treatment with Extensive Surgery and Review of the Literature

Clarijs, Magali; Poot, F.; Laka, Andoni; Pirard, Christian; Bourlond, A

doi:10.1159/000069967

Cited by 46 publications

(33 citation statements)

References 12 publications

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“…GSS must be differentiated from granulomatous mycosis fungoides with the presence of bulky skin lesions, and histologically in the abundant giant cells, elastolysis Testing for T-cell clonality in patients with GSS by PCR or Southern blotting has seldomly been reported. Review of literature confirmed a clonal T-cell population in skin samples from patients with GSS although polyclonal T-cell receptor rearrangement could be found in a few cases [4,6,[9][10][11]. In our patient, monoclonal rearrangement of T-cell D-c receptor gene was detected in the skin lesion.…”

Section: Discussionsupporting

confidence: 67%

“…Some authors claimed that GSS was a benign disorder, and a variant of cutaneous T-cell lymphoma [4]. In contrary, some authors suggested that GSS was a precursor of malign lymphoma, especially Hodgkin's disease [7,10,14,15]. However, in the literature, 58% of cases had not been associated with any lymphoproliferative malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…There is no known standard or effective treatment for GSS [10]. The disease itself is not life threatening, but data about the prognosis of GSS is not enough.…”

Section: Discussionmentioning

confidence: 99%

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Granulomatous slack skin: report of a case with response to electron beam therapy

et al. 2007

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Granulomatous slack skin (GSS) is a rare form of cutaneous T-cell lymphoma, closely related to mycosis fungoides. It is characterized by pendulous skin folds with a predilection for flexural areas. Histology shows an elastolytic granulomatous infiltrate with atypical lymphoid cells. Granulomatous mycosis fungoides is an important histologic differential diagnosis to be considered. We present a 19-year-old man with a gradually enlarging erythematous, and bulky lesions on his body. Histologically, a dense atypical lymphoid cell infiltration with numerous multinucleated giant cells and elastolysis was observed. T-cell receptor gene rearrangement was detected in skin lesions. He was treated with PUVA and interferon alpha, but improvement in skin lesions was not observed. Marked regression of all lesions was achieved by using electron beam therapy. This case report supports that GSS is an indolent variant of mycosis fungoides due to clinical, histological and T-cell gene rearrangement results. However, there is no definitive data about prognosis of the disease. We suggest that further clinical studies are needed to understand this rare condition.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

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Granulomatous slack skin: report of a case with response to electron beam therapy

et al. 2007

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“…In approximately one-third of the reported patients, an association with Hodgkin lymphoma was observed, and association with classical MF has also been reported. [75][76][77] Most patients have an indolent clinical course ( Table 2).…”

Section: Variants and Subtypes Of Mycosis Fungoidesmentioning

confidence: 99%

WHO-EORTC classification for cutaneous lymphomas

Willemze

Jaffe

Burg

et al. 2005

Blood

3,518

4,355

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“…Treatment is difficult due to the recurrence of lesions. Radiotherapy is a good option for localized disease, and surgical removal may be performed on redundant skin that causes discomfort to the patient 37 . Occasionally, granulomatous slack skin may be associated with classical MF or Hodgkin's lymphoma; thus, investigation is imperative to exclude such associations 38 .…”

Section: Cmjmentioning

confidence: 99%

Cutaneous lymphomas: A review

Miyashiro¹,

Sanches²

2015

Cumhuriyet Med J

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SUMMARYSkin may be affected by non-Hodgkin lymphomas, and it is the second most frequently involved extranodal organ, after the gastrointestinal tract. Cutaneous lymphomas may originate from T, B, or NK lymphocytes. Diagnosis is difficult, and knowledge of these diseases is important to ensure their detection and adequate treatment and follow-up. Clinical picture is heterogeneous, and histology is essential to confirm the diagnosis. The classification is given by the correlation between clinical findings, histology and immunophenotyping. Therapeutic options include skin-directed therapies, immunomodulatory or low-dose immunosuppressive drugs. Rare cases of aggressive disease require systemic multidrug chemotherapy. The purpose of this review is to describe the ontogeny of T, B and NK lymphocytes, and to detail the most accepted classification of cutaneous lymphomas, proposed by the World Health Organisation and European Organisation for Research and Treatment of Cancer. Treatment of cutaneous lymphomas will be briefly discussed.

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Granulomatous Slack Skin: Treatment with Extensive Surgery and Review of the Literature

Cited by 46 publications

References 12 publications

Granulomatous slack skin: report of a case with response to electron beam therapy

Granulomatous slack skin: report of a case with response to electron beam therapy

WHO-EORTC classification for cutaneous lymphomas

Cutaneous lymphomas: A review

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