Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid

Tomita, Naoto; Kanamori, Heiwa; Fujita, Hiroyuki; Maruta, Atsuo; Naitoh, Atsushi; Nakamura, Satoshi; Ota, Yasuhiro; Nozue, Norio; Kihara, Minoru; Ishigatsubo, Yoshiaki

doi:10.1097/00001813-200109000-00005

Cited by 17 publications

(7 citation statements)

References 10 publications

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“…For example, retinoids can induce iNOS expression in vivo [93], and enhance IL-8 [94] and ICAM-1 [37] expression in vitro. Further, since tRA has been shown to potentiate tubulointerstitial nephritis both in patients and in animal models [16,17], retinoids may also have proinflammatory effects on renal tubulointerstitial cells. In support of this hypothesis, midkine, a RA-inducible gene product, is reported to be involved in neutrophil infiltration in the tubulointerstitium in ischemic renal injury [95].…”

Section: Evidence Of the Proinflammatory Effects Of Retinoidsmentioning

confidence: 99%

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Retinoids in nephrology: Promises and pitfalls

Lucio-Cazaña

Kitamura

et al. 2004

Kidney International

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Section: Evidence Of the Proinflammatory Effects Of Retinoidsmentioning

confidence: 99%

“…peutic effects in various experimental kidney diseases, as shown in Table 1 [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. To date, three groups of retinoids have been isolated or synthesized ( Table 2) [1-4, 6, 12, 13, 19, 20].…”

mentioning

confidence: 99%

Retinoids in nephrology: Promises and pitfalls

Lucio-Cazaña

Kitamura

et al. 2004

Kidney International

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“…Most cases of AKI are found in the setting of the combination of RAS with nephrotoxic medications leading to acute tubular necrosis. There is one case reported of AKI with granulomatous interstitial nephritis [8]. There is a single report from Korea that describes an adult with APL who developed nephrotic range proteinuria, maximum 19.24 g/day, 14 days after the start of ATRA therapy [9].…”

Section: Discussionmentioning

confidence: 99%

“…For the induction phase, the patient started ATRA 10 mg BID (~12.5 mg/m 2 /dose) 3 days prior to chemotherapy to complete 30 days. The chemotherapy given during induction consisted of daunorubicin (28 mg daily,~50 mg/m 2 /dose on days 3, 4, 5, 6) and cytarabine (40 mg BID,~3.3 mg/kg/dose on days 3,4,5,6,7,8,9). The patient also received the following medications during induction therapy for prophylaxis and episodes of febrile neutropenia: vancomycin, cefepime, TMP-SMX, amikacin, meropenem, voriconazole, fluconazole, pentamidine, and allopurinol.…”

Section: Case Reportmentioning

confidence: 99%

Nephrotic-range proteinuria in a child with retinoic acid syndrome

et al. 2011

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“…Acute renal failure in elderly patients with the nephrotic syndrome from minimal-change disease is well recognized. [14][15][16][17] The earliest descriptions were published in the late 1960s. These patients often have superimposed acute tubular necrosis.…”

Section: Acute Renal Failure and The Nephrotic Syndromementioning

confidence: 99%

Case 36-2003

Singh

Colvin²

2003

N Engl J Med

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A 68-year-old woman was admitted to the hospital because of impaired renal function. One month earlier, she had had difficulty breathing and had felt as though she had a fever; she went to another hospital, where nebulizers were prescribed, and her dyspnea improved. Two weeks later, malaise and a sensation of chilliness developed, with diffuse pains in the arms and legs, which prompted her to take two or three tablets of ibuprofen every four to five hours for two weeks, although the medication was only minimally effective. Ten days before admission, pruritus developed. She consulted a physician, who found that her temperature was 37.8°C and prescribed cetirizine.Four days later, she consulted her customary physician. The urine was ++ for protein; the sediment contained 50 to 100 white cells and moderate numbers of tubular cells. The urea nitrogen level was 20 mg per deciliter (7.1 mmol per liter), and the creatinine level 1.5 mg per deciliter (132.6 µmol per liter), although previously, the creatinine level had been around 0.8 mg per deciliter (70.7 µmol per liter). She was advised to discontinue taking ibuprofen and to return for follow-up, but on the day of admission she vomited twice, felt extremely fatigued, continued to have malaise, and produced less urine than usual. She was admitted to the hospital.The patient had a history of hypertension. Six years before admission, she had had an abdominal hysterectomy with incidental appendectomy because of endometrial carcinoma. She had smoked one pack of cigarettes daily for 20 years but had stopped smoking 30 years before admission. She consumed wine with dinner. She resided with her husband and had several children, one of whom had multiple sclerosis. Her medications were hydrochlorothiazide, conjugated equine estrogens, aspirin, and a multivitamin tablet, as well as ibuprofen. She had no recurrence of dyspnea or fever, and she reported not having had frank chills, chest pain, abdominal pain, diarrhea, dysuria, polyuria, arthralgia, or rash or having recently traveled.The temperature was 37.3°C, the pulse 66 beats per minute, and the respiratory rate 20 breaths per minute. The blood pressure was 110/75 mm Hg. The oxygen saturation was 99 percent while the patient breathed ambient air. On physical examination, there was no rash or lymphadenopathy, and no petechiae were found. The jugular venous pressure was 7 cm of blood. The lungs were clear, and the heart sounds were normal. The abdomen was unremarkable. There was trace peripheral edema, and the pulses at the hands and feet were intact. case records of the massachusetts general hospital 2057 * To convert the values for phosphorus to millimoles per liter, multiply by 0.3229. To convert the values for cholesterol to millimoles per liter, multiply by 0.02586. To convert the value for triglycerides to millimoles per liter, multiply by 0.01129. To convert the value for magnesium to milliequivalents per liter, divide by 0.5. To convert the values for urea nitrogen to millimoles per liter, multiply by 0.357. To convert ...

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Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid

Cited by 17 publications

References 10 publications

Retinoids in nephrology: Promises and pitfalls

Retinoids in nephrology: Promises and pitfalls

Nephrotic-range proteinuria in a child with retinoic acid syndrome

Case 36-2003

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