Granulomatous vasculitis in crohn's disease

Wakefield, Andrew J.; Sankey, E A; Dhillon, Amar P.; Sawyerr, A. M.; More, L; Sim, R; Pittilo, R. M.; Rowles, P M; Hudson, Mark; Lewis, A. A. M.; Pounder, R E

doi:10.1016/0016-5085(91)90779-k

Cited by 238 publications

(101 citation statements)

References 7 publications

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“…Disease progression appears to initiate once autoreactive cytotoxic CD8 ϩ T-cells migrate to the gastrointestinal tract and kill EGCs, initially targeting the submucosal plexus closely juxtaposed to blood vessels. Importantly, the resulting pathology initiates as a submucosal vasculitis reminiscent of that described for Crohn's disease (Wakefield et al, 1991) and subsequently leads to disruption of the mucosal epithelial barrier and induction of a type 1 cytokine response. Pathology in these mice occurred without any obvious detrimental effect on enteric neurons, suggesting that EGC function itself plays an essential role in maintaining normal epithelial and vascular integrity in the gastrointestinal tract, and that fulminating tissue inflammation and necrosis ensue when the EGC network is disrupted.…”

Section: Transgenic Mouse Models To Study Egc Pathophysiology and Ibdmentioning

confidence: 99%

“…Early pathological manifestations of Crohn's disease include T-cell infiltration of myenteric plexi, enteric neuronal pathology, and vascular disturbances (Wakefield et al, 1991;D'Haens et al, 1998;Geboes and Collins, 1998). These features are modeled in (GFAP-HA ϫ HA-TCR)F1 double transgenic mice in which EGCs are lysed by autoreactive T-cells.…”

Section: Enteric Glial Cells In Human Ibdmentioning

confidence: 99%

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Role of enteric glial cells in inflammatory bowel disease

Cabarrocas

Savidge

Liblau

2002

Glia

160

154

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Enteric glial cells (EGCs) represent an extensive but relatively poorly described cell population within the gastrointestinal tract. Accumulating data suggest that EGCs represent the morphological and functional equivalent of CNS astrocytes within the enteric nervous system (ENS). The EGC network has trophic and protective functions toward enteric neurons and is fully implicated in the integration and the modulation of neuronal activities. Moreover, EGCs seem to be active elements of the ENS during intestinal inflammatory and immune responses, sharing with astrocytes the ability to act as antigen-presenting cells and interacting with the mucosal immune system via the expression of cytokines and cytokine receptors. Transgenic mouse systems have demonstrated that specific ablation of EGC by chemical ablation or autoimmune T-cell targeting induces an intestinal pathology that shows similarities to the early intestinal immunopathology of Crohn's disease. EGCs may also share with astrocytes the ability to regulate tissue integrity, thereby postulating that similar interactions to those observed for the blood-brain barrier may also be partly responsible for regulating mucosal and vascular permeability in the gastrointestinal tract. Disruption of the EGC network in Crohn's disease patients may represent one possible cause for the enhanced mucosal permeability state and vascular dysfunction that are thought to favor mucosal inflammation. GLIA 41:81-93, 2003.

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Section: Transgenic Mouse Models To Study Egc Pathophysiology and Ibdmentioning

confidence: 99%

Section: Enteric Glial Cells In Human Ibdmentioning

confidence: 99%

Role of enteric glial cells in inflammatory bowel disease

Cabarrocas

Savidge

Liblau

2002

Glia

160

154

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“…Crohn's disease is associated with widespread granulomatous and lymphocytic microvascular inflammation (Wakefield et al, 1991). Both tissue factor expression (More et al, 1993) and fibrin deposition in foci of endothelial cell injury, with thrombotic occlusion of inflamed blood vessels, are phenotypic features of this condition (Wakefield et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Measles Virus Induction of Human Endothelial Cell Tissue Factor Procoagulant Activity in Vitro

Mazure

Grundy

Nygård

et al. 1994

Journal of General Virology

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“…Examples of intestinal vasculitis have also been reported in Churg-Strauss syndrome, Behçet's disease, polyarteritis nodosa, and Henoch-Schönlein purpura, but venous inflammation is not a frequent feature of these entities [5]. Ischemic lesions due to vasculitis limited to gastrointestinal sites have also been reported in association with Crohn's disease, and the inflammatory process also affects the arterial vasculature [1,3].…”

Section: Discussionmentioning

confidence: 99%

“Enterocolic phlebitis” mimicking a primary tumor of the cecum – A rare presentation of an unusual entity

Cruz

Almeida

Soares

2009

Pathology - Research and Practice

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Intestinal vasculitis is an infrequent entity in the absence of systemic vasculitis or chronic inflammatory bowel disease. The primary involvement of gut restricted to mesenteric venous territory is exceedingly rare. We report a pseudotumoural lesion of the cecum caused by localized phlebitis and venulitis associated with thrombosis, with a putative immune etiology, in a young adult presenting with obstructive intestinal crisis.

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Granulomatous vasculitis in crohn's disease

Cited by 238 publications

References 7 publications

Role of enteric glial cells in inflammatory bowel disease

Role of enteric glial cells in inflammatory bowel disease

Measles Virus Induction of Human Endothelial Cell Tissue Factor Procoagulant Activity in Vitro

“Enterocolic phlebitis” mimicking a primary tumor of the cecum – A rare presentation of an unusual entity

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