Granulome cérébral à Candida albicans chez un patient immunocompétent. Cas clinique

Borha, Alin; Parienti, Jean‐Jacques; Emery, Évelyne; Coskun, O.; Khouri, S.; Derlon, J M

doi:10.1016/j.neuchi.2008.06.001

Cited by 15 publications

(10 citation statements)

References 28 publications

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“…The identification of these mutations in descendants from France might also explain previous reports of sCNSc in French persons. [32][33][34] To understand the molecular basis of CARD9 deficiency, we evaluated the ''canonical'' pathway, whereby CARD9 complexes with BCL10 and MALT1, and found no difference in these interactions. These findings suggest that CARD9 deficiency does not confer susceptibility to invasive fungal disease through this pathway, which is consistent with the absence of invasive fungal disease in families with deficiency of BCL10 35 or MALT1.…”

Section: Discussionmentioning

confidence: 99%

Impaired RASGRF1/ERK–mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians

Gavino

Hamel

Zeng

et al. 2016

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

Impaired RASGRF1/ERK–mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians

Gavino

Hamel

Zeng

et al. 2016

Journal of Allergy and Clinical Immunology

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“…Interestingly, fifty percent of patients with disseminated candidiasis underwent CNS fungal invasion [ 23 ]. Even though C. albicans is usually more prevalent in immunocompromised individuals, it has also been reported to cause meningoencephalitis in healthy individuals [ 24 ]. Considering these aspects and the fact that a possible relationship between Candida spp.…”

Section: Discussionmentioning

confidence: 99%

Experimental Autoimmune Encephalomyelitis Development Is Aggravated byCandida albicansInfection

Fraga-Silva

Mimura

Marchetti

et al. 2015

Journal of Immunology Research

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Multiple sclerosis (MS) is an inflammatory/autoimmune disease of the central nervous system (CNS) mainly mediated by myelin specific T cells. It is widely believed that environmental factors, including fungal infections, contribute to disease induction or evolution. Even though Candida infection among MS patients has been described, the participation of this fungus in this pathology is not clear. The purpose of this work was to evaluate the effect of a Candida albicans infection on experimental autoimmune encephalomyelitis (EAE) that is a widely accepted model to study MS. Female C57BL/6 mice were infected with C. albicans and 3 days later, animals were submitted to EAE induction by immunization with myelin oligodendrocyte glycoprotein. Previous infection increased the clinical score and also the body weight loss. EAE aggravation was associated with expansion of peripheral CD4+ T cells and production of high levels of TNF-α, IFN-γ IL-6, and IL-17 by spleen and CNS cells. In addition to yeast and hyphae, fungus specific T cells were found in the CNS. These findings suggest that C. albicans infection before EAE induction aggravates EAE, and possibly MS, mainly by CNS dissemination and local induction of encephalitogenic cytokines. Peripheral production of encephalitogenic cytokines could also contribute to disease aggravation.

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“…In infants, meningitis is more common than in older patients. Candida meningitis is rarely but occasionally described in healthy people or after neurosurgical procedures (Nguyen and Yu, 1995;Borha et al, 2009). Cryptococcus neoformans is the most common causative agent for chronic lymphocytic fungal meningitis.…”

Section: Clinical Featuresmentioning

confidence: 99%

CSF in acute and chronic infectious diseases

Benninger

Steiner

2018

Handbook of Clinical Neurology

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Infections of the nervous system are an important and challenging aspect of clinical neurology. Immediate correct diagnosis enables to introduce effective therapy, in conditions that without diagnosis may leave the patient with severe neurological incapacitation and sometimes even death. The cerebrospinal fluid (CSF) is a mirror that reflects nervous system pathology and can promote early diagnosis and therapy. The present chapter focuses on the CSF findings in neuro-infections, mainly viral and bacterial. Opening pressure, protein and glucose levels, presence of cells and type of the cellular reaction should be monitored. Other tests can also shed light on the causative agent: serology, culture, staining, molecular techniques such as polymerase chain reaction. Specific examination such as panbacterial and panfungal examinations should be examined when relevant. Our chapter is a guide-text that combines clinical presentation and course with CSF findings as a usuaful tool in diagnosis of neuroinfections. ACUTE INFECTIOUS DISEASES OF THE NERVOUS SYSTEMAcute infections of the nervous system are as diverse in their clinical consequences for the patient as the variety of infectious agents causing them: from mild headaches to long-term morbidity and a threat to life. Therefore, the earliest possible diagnosis is absolutely essential. Central here stands the examination of the CSF. The correct diagnosis is often dependent on this rather simple procedure to allow diagnosis and focused antimicrobial and adjunctive therapy. This chapter deals with acute infectious diseases of the nervous system and the importance of the lumbar puncture (LP) in the diagnostic process.

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Granulome cérébral à Candida albicans chez un patient immunocompétent. Cas clinique

Cited by 15 publications

References 28 publications

Impaired RASGRF1/ERK–mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians

Impaired RASGRF1/ERK–mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians

Experimental Autoimmune Encephalomyelitis Development Is Aggravated byCandida albicansInfection

CSF in acute and chronic infectious diseases

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