Granulopoiesis in systemic lupus erythematosus

Yamasaki, Kazuo; Niho, Yoshiyuki; Yanase, Toshiyuki

doi:10.1002/art.1780260410

Cited by 25 publications

(16 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our study, use of immunosuppressive drugs did not increase the risk of neutropenia development. However, low hemoglobin, platelet, and leukocyte count detected at the admissions were shown to be associated with neutropenia in our study suggesting that primary bone marrow abnormalities might contribute to development of neutropenia [9,26]. Chronic kidney disease that might reflect lupus nephritis was revealed as an independent risk factor for neutropenia in SLE patients in this study.…”

Section: Discussioncontrasting

confidence: 54%

“…The pathogenesis of neutropenia in SLE is not entirely understood, but both humoral and cellular immune responses are known to be involved. Increased peripheral destruction of granulocyte by circulating antineutrophil antibodies [7], increased margination or changes in marginal and splenic pool [8], and decreased granulocytopoiesis in the bone marrow [9,10] were suggested as potential mechanisms. Clinically, neutropenia in SLE patients can increase susceptibility to recurrent infection [3,11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and Risk Factors Associated with Neutropenia in Hospitalized Patients with Systemic Lupus Erythematosus

2017

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors Associated with Neutropenia in Hospitalized Patients with Systemic Lupus Erythematosus

2017

View full text Add to dashboard Cite

show abstract

“…However, possible mechanisms involve increased peripheral destruction, decreased bone marrow production, and increased margination of granulocytes [16]. Studies have noted an elevation in circulating IgG anti-neutrophil antibodies leading to complement activation [17] and an increase in TNF-related apoptosis inducing ligand (TRAIL) level [18, 19], as well as evidence for T cell- and monocyte-mediated suppression of granulocytopoiesis in the bone marrow of SLE patients [20]. …”

Section: Discussionmentioning

confidence: 99%

ANA-Negative Presentation of SLE in Man with Severe Autoimmune Neutropenia

Zhao

2016

Case Reports in Medicine

View full text Add to dashboard Cite

Background. Systemic lupus erythematosus (SLE) is a chronic, inflammatory, connective tissue disease that commonly affects the joints and a variety of organs due to an overactivation of the body's immune system. There is wide heterogeneity in presentation of SLE patients, including lung, central nervous system, skin, kidney, and hematologic manifestations. Case Presentation. We report a case of atypical manifestation of SLE in a 53-year-old man who presented with neutropenic fever. Physical findings of interest included oral ulcers on the lower lip, a malar-like rash across the bridge of the nose, and a discoid-like rash on extensor surfaces of the elbows and knees. Labs include ANC <100, weakly positive anti-dsDNA, negative ANA, ferritin 1237 ng/mL, low C3/C4, and positive direct Coombs' test. A thorough workup for infection and hematologic malignancy was negative. Two days after initiation of therapy with 25 mg IV solumedrol twice a day, the patient's daily fevers resolved. ANC drastically improved to 2000 after two weeks of steroid treatment. He was later found to have a high titer of anti-neutrophil antibodies. Discussion. Autoimmune leukopenia is a common presentation in SLE, occurring in 50–60% of patients. Severe autoimmune neutropenia is uncommon and may correlate with high anti-neutrophil antibody activity despite a negative ANA. As neutropenia is usually mild, there are currently no guidelines for therapy. For our patient, we started him on low dose IV solumedrol and found that he responded drastically to treatment. Given strongly positive nonspecific anti-neutrophil antibodies in the setting of a negative ANA noted in our patient, it is likely that there are other currently unknown antibodies associated with SLE which may correlate strongly with autoimmune neutropenia.

show abstract

“…Despite chronic neutropenia and hyper-susceptibility to bacterial infections [15][16][17], a significant proportion of SLE patients display elevated levels of immature neutrophils and a pronounced granulopoiesis gene expression signature in cells from both peripheral blood and bone marrow exudates [2,18,19]. In addition, neutrophils are known to infiltrate target organs such as the skin, kidney or vasculature in SLE patients [20][21][22], although the pathogenic nature of such infiltration remains unknown.…”

Section: Pro-inflammatory Neutrophils In Accumulate In Sle Patients Amentioning

confidence: 99%

Pro- and Anti-inflammatory Neutrophils in Lupus

Der¹,

Trigunaite²,

Khan³

et al. 2014

J Clin Cell Immunol

View full text Add to dashboard Cite

A hallmark of SLE is the presence of elevated levels of circulating anti-nuclear autoantibodies specific towards chromatin, histones or dsDNA. Understanding the regulation of antibody production is therefore of utmost importance in understanding lupus pathogenesis. Spearheaded by the identification of accumulating immunosuppressive neutrophils in cancer patients, the nature and function of neutrophils have expanded from a uniform pro-inflammatory cell population to a heterogeneous population of cells with pro-inflammatory or immunosuppressive capacities. While much is known about pro-inflammatory neutrophils and the likely pathogenic function of such cells in lupus, a potential role for immunosuppressive neutrophils in protecting genetically predisposed individuals has only recently emerged. For example, SLE-derived neutrophils spontaneously produce type I interferons (IFNα), strongly associated with disease development, release chromatin-containing neutrophil extracellular traps (NETs), potentially functioning as a source of nuclear auto-antigen, and may activate B cells in a T cell independent fashion. In contrast, levels and functions of regulatory neutrophils (Nregs) involved in T celldependent B cell differentiation and germinal center reactions, are dysregulated in female lupus-prone mice during disease development. Here we review data supporting a role for both pro-and anti-inflammatory neutrophils in lupus.

show abstract

Granulopoiesis in systemic lupus erythematosus

Cited by 25 publications

References 36 publications

Prevalence and Risk Factors Associated with Neutropenia in Hospitalized Patients with Systemic Lupus Erythematosus

Prevalence and Risk Factors Associated with Neutropenia in Hospitalized Patients with Systemic Lupus Erythematosus

ANA-Negative Presentation of SLE in Man with Severe Autoimmune Neutropenia

Pro- and Anti-inflammatory Neutrophils in Lupus

Contact Info

Product

Resources

About