Granulosa cell tumour: An interesting case in a pregnant mare

Abstract

Summary This report describes the successful management of a pregnant 14‐year‐old seven‐eighths Thoroughbred mare with an ovarian granulosa cell tumour. The mare initially presented with unilateral ovarian enlargement whilst being managed for artificial insemination, demonstrating normal ovarian function with ovulation from the contralateral ovary leading to conception. The mare subsequently re‐presented with stallion‐like behaviour at 3.5 months gestation and ovarian suppression was evident. The mare maintained her pregnancy and delivered a live colt foal at term. Ovariectomy was performed 3 months post foaling and the mare regained cyclic activity 9 months post surgery. The mare then conceived and became pregnant once more. The diagnostic and therapeutic challenges during pregnancy are discussed.

Granulosa cell tumours ‐ diagnostic considerations

“…There are reports of mares that have a GCT successfully conceiving and maintaining a pregnancy (Crabtree et al . ), confirming that normal ovulation and corpus luteum development can occur, at least early in the disease process.…”

“…This can range from an incidental finding in a normal reproductive examination (Crabtree et al . ) to behavioural abnormalities such as prolonged anoestrus, stallion‐like behaviour and persistent oestrus (Meagher et al . 1977; Stabenfeldt et al .…”

Ascites in a 13‐year‐old miniature horse mare with an ovarian granulosa theca‐cell tumour: A manifestation ofMeigs' syndrome?

“…), and while they have been diagnosed primarily in nongravid mares, a recent report documents the management of GCT during pregnancy (Crabtree et al . ).…”

“…GCTs have also been reported in conjunction with hypertrophic osteopathy (Packer and McKane 2012), obstruction of the small colon (Mair 2002), and haemoperitoneum (Gatewood et al 1990;Alexander et al 2004). Also recently described are 2 cases in which GCTs had significant adhesions to other abdominal organs (Rambags et al 2003), and while they have been diagnosed primarily in nongravid mares, a recent report documents the management of GCT during pregnancy (Crabtree et al 2013).…”

Tumour, or not tumour, that is the question

“…The case report by Crabtree et al . (2013) provides an excellent review of granulosa cell tumours (GCT) in mares.…”