Granulosa cells apoptosis and follicular fluid hormones: comparison of progestin-primed ovarian stimulation versus GnRH antagonist protocols

Li, Xiaolan; Zhang, Xiaoli; Cai, Jiawei; Pang, Jiahui; Sun, Peng; Chen, Jianhui; Wang, Meng; Liang, Xiaoyan

doi:10.1080/09513590.2020.1822802

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…Merviel et al [17] GnRH-A ≤0.5 >0. 5 No influence (119) (151) Benmachiche et al [18] Eftekhar et al [29] GnRH-A <1.49 [53] GnRH-a down-regulation <0.5 >0.5 LH < 0.5 IU/L increased risk of early pregnancy loss (98) (102) Balasch et al [60] GnRH-a down-regulation <1 (44) or ≤0.7 (21) or ≤0.5 (10) or >0.5 (134) No influence ≥1 (100) >0.7 (123) Humaidan et al [54] GnRH-a down-regulation <0.5 0.51-1.0…”

Section: Discussionmentioning

confidence: 99%

“…(3) women who received three or more IVF/ICSI treatment cycles; (4) sperm or oocyte donation; (5) women with severe organic diseases of the uterus, such as severe uterine cavity adhesions, and uterine fibroids (>4 cm); (6) women with other serious medical or surgical complications, such as diabetes, hyperthyroidism, and hypothyroidism; and (7) women who had recurrent abortion (Fig. 1).…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…An individualized and carefully controlled ovarian hyperstimulation (COH) protocol is critical for successful IVF/ICSI [2] . Recently, the gonadotropin (Gn)-releasing hormone antagonist (GnRH-A) protocol has been widely used in patients receiving IVF/ICSI [3][4][5] . Using this protocol can suppress the release of pituitary Gn and reduce the secretion of endogenous luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which consequently prevent premature LH surges and reduce the risk of ovarian hyperstimulation syndrome (OHSS) [6,7] .…”

Section: Introductionmentioning

confidence: 99%

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Association between LH level decrease on the triggering day and pregnancy outcome for IVF/ICSI patients following GnRH antagonist protocol: a retrospective cohort study

Tang

Wang

et al. 2023

Reproductive and Developmental Medicine

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Objective: Optimal luteinizing hormone (LH) levels for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) patients following the gonadotropin-releasing hormone (GnRH) antagonist protocol remain controversial. This study aimed to estimate the association between serum LH levels on the triggering day (LHLOT) and clinical pregnancy outcomes in IVF/ICSI patients following the GnRH antagonist protocol. Methods: We enrolled 4743 IVF/ICSI cycles using flexible or fixed GnRH antagonist protocols between January 2017 and June 2021. The patients were stratified into four groups according to the LHLOT quartiles (Q1–Q4). Each group was further divided into two subgroups according to the median basal LH/LHLOT. The main outcomes were clinical pregnancy, birth, and miscarriage rates. Secondary outcomes were oocyte yield, number of MII, fertilized oocytes (2PN), and high-quality embryos. Results: Serum LHLOT levels were negatively correlated with oocyte yield and the numbers of MII, 2PN, and high-quality embryos. Reproductive outcomes were compared among the different quartiles and subgroups. The absolute difference in the clinical pregnancy rates between the Q4 and Q1 groups was 6.4% (47.2% vs. 40.8%, P <0.05). Clinical pregnancy rates between the subgroups with basal LH/LHLOT >3.04 and ≤3.04 were 32.7% and 48.6% (P <0.01), respectively, in Q1. Within Q3, the clinical pregnancy rates between the subgroups with basal LH/LHLOT >2.14 and ≤2.14 were 50.2% and 41.9%, respectively (P <0.05). The greater the decrease in LH levels, the lower the oocyte maturation rate across all quartiles. Conclusions: According to the LHLOT quartiles, the Q1 of serum LHLOT <1.43 IU/L may result in a higher number of oocytes but reduced oocyte maturation and lower clinical pregnancy rates. A decrease in LH levels by approximately 2.14 to 3.04 times compared to basal LH levels may lead to higher clinical pregnancy rates in IVF/ICSI patients following the GnRH antagonist protocol.

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