Granulosis Rubra Nasi Response to Topical Tacrolimus

Abstract

Granulosis Rubra Nasi (GRN) is a rare disorder of the eccrine glands. It is clinically characterized by hyperhidrosis of the central part of the face, most commonly on the tip of the nose, followed by appearance of diffuse erythema over the nose, cheeks, chin, and upper lip. It is commonly seen in childhood but it can present in adults. Here we report a case of GRN in an adult patient with very unusual histopathological presentation.

Granulosis rubra nasi: A rare dermatosis not limited to nose

“…GRN is a rare focal form of hyperhidrosis that usually manifest in childhood and disappears during puberty. Primary hyperhidrosis leading to sweat retention localized to central region of face is the principal reason 4 . GRN worsens in summer and can resolve during winter 2 .…”

“…However, lesions may reoccur despite above‐mentioned therapy. GRN has a good prognosis with minimal complication and self‐resolves in most cases 4 …”

“…Primary hyperhidrosis leading to sweat retention localized to central region of face is the principal reason. 4 GRN worsens in summer and can resolve during winter. 2 GRN clinically manifests as asymptomatic skin‐coloured to erythematous macules, papules, pustules, and comedones‐like lesions mainly on tip of the nose.…”

Granulosis Rubra Nasi: A Case Report and Brief Review of the Literature

“…Te tip of the nose is usually red/ violet, cold, and not infltrated. Tis condition is usually asymptomatic except for mild pruritus [7]. Heid et al had reported an association with rhinorrhea [6].…”

Eponymous dermatological contributions linked to Josef Jadassohn

“…Granulosis rubra nasi -It is a disease of eccrine sweat glands, first described by Jadassohn in 1901 as "nasi hyperhidrotic erythematosa micropapules dermatosis infantum." 6 Usually, it starts during childhood as localized hyperhidrosis on the central face, typically affecting the tip, alae and dorsum of the nose. This is followed by secondary changes like blanchable erythema, papulo-vesicles and pustules.…”