Grape seed powder increases gastrointestinal motility

Abstract

Grape seed is an important natural bioactive product with various health benefits. Interstitial cells of Cajal (ICCs) are pacemaker cells in the gastrointestinal (GI) tract. The present study investigated the effects of grape seed powder (GSP) on ICC properties and GI motility. GSP depolarized the pacemaker potentials of ICCs in a dose-dependent manner. Y25130 or SB269970 slightly inhibited GSP-induced effects. However, Y25130 and SB269970 together completely blocked GSP-induced effects. In the presence of inhibitors of protein kinase C, protein kinase A, or mitogen-activated protein kinase, GSP-induced ICC depolarization was inhibited. GSP increased the intestinal transit rate in normal mice and in mice with acetic acid-induced GI motility disorder. In addition, the levels of motilin and substance P were elevated after GSP dosing. These results demonstrate that GSP can regulate GI motility, and therefore, it is a potential therapeutic agent for treating GI motility disorders.

The efficacy of natural products for the treatment of nasopharyngeal carcinoma

“…Grape seed is a major source of catechins and proanthocyanidins, which is readily inexpensive, and beneficial to human health (Choi et al., 2022). Grape seed proanthocyanidins (GSPs) treatment decreased CNE‐2 cell viability and significantly induced G2/M phase cell cycle arrest in human NPC.…”

The Probiotic Combination of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 Alleviates Gastrointestinal Motility Disorder via Improving Gut Microbiota

“…Currently, drug therapy, such as laxatives and prokinetics, is still the main treatment method for GI motility disorders, with some limitations, including the single target of action, susceptibility to diarrhea, and high recurrence rate after drug discontinuation [ 4 , 5 ]. More new therapeutic options have been researched, such as probiotics, prebiotics, microbial metabolites, and natural ingredients from plants [ 6 , 7 , 8 , 9 ].…”