Grape seed proanthocyanidins ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes: An in vivo study

Karthikeyan, Kaliaperumal; Bai, Bing; Devaraj, S. Niranjali

doi:10.1016/j.lfs.2007.09.033

Cited by 57 publications

(36 citation statements)

References 35 publications

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“…Recently, there has been an upsurge of interest to explore the cardioprotective potential of natural products (Karthikeyan et al 2007). Natural products have lesser side effects than synthetic drugs.…”

Section: Introductionmentioning

confidence: 99%

Caffeic acid protects rat heart mitochondria against isoproterenol-induced oxidative damage

Kumaran

Prince

2010

Cell Stress and Chaperones

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Cardiac mitochondrial dysfunction plays an important role in the pathology of myocardial infarction. The protective effects of caffeic acid on mitochondrial dysfunction in isoproterenol-induced myocardial infarction were studied in Wistar rats. Rats were pretreated with caffeic acid (15 mg/kg) for 10 days. After the pretreatment period, isoproterenol (100 mg/kg) was subcutaneously injected to rats at an interval of 24 h for 2 days to induce myocardial infarction. Isoproterenol-induced rats showed considerable increased levels of serum troponins and heart mitochondrial lipid peroxidation products and considerable decreased glutathione peroxidase and reduced glutathione. Also, considerably decreased activities of isocitrate, succinate, malate, α-ketoglutarate, and NADH dehydrogenases and cytochrome-C-oxidase were observed in the mitochondria of myocardial-infarcted rats. The mitochondrial calcium, cholesterol, free fatty acids, and triglycerides were considerably increased and adenosine triphosphate and phospholipids were considerably decreased in isoproterenol-induced rats. Caffeic acid pretreatment showed considerable protective effects on all the biochemical parameters studied. Myocardial infarct size was much reduced in caffeic acid pretreated isoproterenol-induced rats. Transmission electron microscopic findings also confirmed the protective effects of caffeic acid. The possible mechanisms of caffeic acid on cardiac mitochondria protection might be due to decreasing free radicals, increasing multienzyme activities, reduced glutathione, and adenosine triphosphate levels and maintaining lipids and calcium. In vitro studies also confirmed the free-radicalscavenging activity of caffeic acid. Thus, caffeic acid protected rat's heart mitochondria against isoproterenolinduced damage. This study may have a significant impact on myocardial-infarcted patients.

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Section: Introductionmentioning

confidence: 99%

Caffeic acid protects rat heart mitochondria against isoproterenol-induced oxidative damage

Kumaran

Prince

2010

Cell Stress and Chaperones

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“…Since lysosomal hydrolases have been implicated in the propagation of the cellular injury during the early stages of acute MI and this action is crucial in protecting the heart against ischemic damage. Lysosomal destabilization may be prevented either by inhibition of cellular peroxidation or by prevention of iron catalyzed oxidative reactions, which involve peroxidation of cellular membranes, energy depletion and leakage of lysosomal content (Karthikeyan et al 2007). It is possible that stabilization of myocardial cell membranes, particularly the lysosomal membranes, may prolong the viability of ischemic cardiac muscle.…”

Section: Tablementioning

confidence: 99%

Pretreatment with a combination of quercetin and α-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats

Punithavathi

Prince

2010

Life Sciences

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“…3 Isoproterenol (ISO) is an adrenergic agonist and acute administration of ISO in experimental animals causes necrosis to heart muscle. 4 ISO damages the myocardial via calcium accumulation in cytosolic membrane, generation of reactive oxygen species and procogulant activity. 5 ISO causes the patchy pathological changes in the myocardial tissue, which is almost clinically relevant to myocardial infarction of ischemic heart disease.…”

Section: Introductionmentioning

confidence: 99%

Role of Ginkgo biloba Extract, Against Isoproterenol Induced Cardiac Toxicity in Rats

Badore¹,

Das²,

Pillai³

et al. 2017

IJPER

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Objective: Ginkgo biloba is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the cardio protective role of chronic oral administration of Ginkgo biloba leaf extract against Isoproterenol induced myocardial injury. Material and methods: Male Wistar albino rats were randomly divided into five groups (n = 6) and treated as per treatment protocol with three different dose of Ginkgo biloba extract (125, 250, and 500 mg/kg b.w.) orally for thirty days. At the end of the treatment all the rats (except control rats) were administered with Isoproterenol (85 mg/kg) two consecutive days and subjected to biochemical and histopathological estimation. Results: Isoproterenol (group II) induced the oxidative myocardial damage via alteration in the endogenous antioxidant enzymes and myocardial marker enzymes. Ginkgo biloba extract in all three dose (group III, IV and V) shows protective mechanism via decreasing thiobarbituric acid reactive substance (TBARS) and enhancing the endogenous antioxidant enzymes (reduced glutathione (GSH), superoxide dismutase (SOD) and catalase). The extract effect was compared with the reference standard α-tocopherol which also offered similar protection in biochemical and histopathological changes. Conclusion: Thus, the study shows that Ginkgo biloba extract exhibits significant antioxidant activity and protect the heart from free radical mediated toxicity of Isoproterenol.

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Grape seed proanthocyanidins ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes: An in vivo study

Cited by 57 publications

References 35 publications

Caffeic acid protects rat heart mitochondria against isoproterenol-induced oxidative damage

Caffeic acid protects rat heart mitochondria against isoproterenol-induced oxidative damage

Pretreatment with a combination of quercetin and α-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats

Role of Ginkgo biloba Extract, Against Isoproterenol Induced Cardiac Toxicity in Rats

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