2016
DOI: 10.1590/s0102-865020160030000006
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Grape seed protects cholestatic rats liver from ischemia/reperfusion injury

Abstract: PURPOSE:To determine the effect of grape-seed extract against ischemia/reperfusion injury in cholestatic liver. METHODS:Eighteen Wistar albino rats were divided into three groups. In control and study groups, cholestasis was provided by bile duct ligation. Seven days later, the rats were subjected to 30 min hepatic ischemia, followed by 60 min of reperfusion. Oral administration of 50 mg/kg/day grape-seed extract was started 15 days before bile duct ligation and continued to the second operation in the study g… Show more

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Cited by 6 publications
(4 citation statements)
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“…Grape seed proanthocyanidin extract (GSPE), the active ingredient in GSE, have been reported to exhibit a broad spectrum of pharmacological and protective effects including contrast‐induced nephropathy as well as renal and hepatic ischemia–reperfusion injuries, in addition to the antioxidative properties as well as an active oxygen free radical scavenging ability. Besides, proanthocyanidins have cytomodulating, antibacterial, antiviral, antioxidant, anti‐apoptotic, and anti‐inflammatory properties (Çakır et al, 2016; Kalfin et al, 2002; Shrotriya et al, 2015). Moreover, GSPE enhances the viability of healthy cells against damaging environmental factors including cancer chemotherapeutic chemicals, and drug‐induced cytotoxicity (Ozkan et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…Grape seed proanthocyanidin extract (GSPE), the active ingredient in GSE, have been reported to exhibit a broad spectrum of pharmacological and protective effects including contrast‐induced nephropathy as well as renal and hepatic ischemia–reperfusion injuries, in addition to the antioxidative properties as well as an active oxygen free radical scavenging ability. Besides, proanthocyanidins have cytomodulating, antibacterial, antiviral, antioxidant, anti‐apoptotic, and anti‐inflammatory properties (Çakır et al, 2016; Kalfin et al, 2002; Shrotriya et al, 2015). Moreover, GSPE enhances the viability of healthy cells against damaging environmental factors including cancer chemotherapeutic chemicals, and drug‐induced cytotoxicity (Ozkan et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…While cholestasis alone increases Kupffer cell activation and may cause FOR release. IR injury that develops in the presence of cholestasis is much more severe [21]. Many surgeons expect the pre-operative bilirubin levels to decrease in patients with very high bilirubin levels in elective operations.…”
Section: Discussionmentioning
confidence: 99%
“…Cakir et al [ 81 ] examined grape seeds and their ability to protect the cholestatic liver against ischemia/reperfusion injury. Eighteen Wistar rats were divided into three groups.…”
Section: Other Studiesmentioning
confidence: 99%
“…Oral administration of GSE altered all these parameters and histopathological findings, with the exception of serum bilirubin levels. In conclusion, oral treatment with GSE can improve liver function and relieve inflammation and oxidative stress in cholestatic ischemia/reperfusion injury [ 81 ].…”
Section: Other Studiesmentioning
confidence: 99%