Grape seeds proanthocyanidin extract as a hepatic-reno-protective agent against gibberellic acid induced oxidative stress and cellular alterations

Abstract

The present study aims to investigate the heptonephro-protective effect of grape seeds proanthocyanidin extract (GSPE) against the risks induced by gibberellic acid (GA3) in male rats. The results recorded that GA3 caused a significant increase in total lipids, total cholesterol, triglycerides and LDL-C levels in serum, concomitant with a significant decrease in serum HDL-C. A significant increase in serum AST, ALT, urea and creatinine, while, a significant decrease in total protein content in serum was observed in rats given GA3. Hepatic and renal lipid peroxidation product (MDA) was significantly increased, meanwhile, total antioxidant capacity (TAC), glutathione, and catalase levels were significantly decreased. In addition, there was a negative change in liver structure including dilatation in the central veins with degeneration of endothelium cells and cellular injury around the veins as well as in the kidney structure such as lesion in both glomeruli and tubules, detachment of the Malpighian corpuscles from the Bowman's capsule's epithelium, shrinkage in the glomerular capillary network. However, almost all of these adverse effects seemed to be ameliorated by oral administration of GSPE with GA3 to rats for 2 month indicating the protective effect of grape seeds GSPE on GA3 induced oxidative stress in rats.

Effects of exogenous tannase enzyme on growth performance, antioxidant status, immune response, gut morphology and intestinal microflora of chicks fed grape pomace

“…Many investigators have demonstrated the efficacy of grape seed proanthocyanidins and grape juice as an inhibitor of lipid peroxidation and as a powerful free radical scavenger in vitro and in vivo (Dani et al, 2008;Khalifa et al, 2011;Naguib, 2011) in addition to its hepatoprotective effect (Hassan & Al-Rawi, 2013). Thus it was suggested that the active component of grapes protect the hepatocytes from liver damage and subsequent leakage of enzymes into the circulation, and may have a curative effect against elevated transaminases (Ahmed & Fatani, 2007;Al-Attar, 2015).…”

Collected Research on Phytonutrients: Flavonoids

“…Grape seed extract contains a proanthocyanidin that contains a particularly higher degree of oxygen free radical scavenger potential. It is also thought to increase the good cholesterol, HDL, while decreasing the bad cholesterol, LDL (Hassan & Al-Rawi, 2012).…”

Proanthocyanidin and its emerging anti-neoplastic effects: recent insights

“…Hassan et al have provided interesting data in their recent article (Hassan et al 2012). Proanthocyanidins exert significant anti-neoplastic effects in many systemic malignancies.…”