2011
DOI: 10.1016/j.foodchem.2010.11.016
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Grape skin extract inhibits mammalian intestinal α-glucosidase activity and suppresses postprandial glycemic response in streptozocin-treated mice

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Cited by 124 publications
(102 citation statements)
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“…Yeast α-glucosidase is available in pure form from commercial sources and has been widely used as a model for investigating antiglucosidase properties of natural products. In grape skin and pomace extracts, inhibition against yeast α-glucosidase correlated with inhibition against mammalian α-glucosidase and suppression of postprandial hyperglycemia in Streptozocininduced diabetic mice [27]. To assess the radical scavenging activity of T. domingensis fruit extracts and fractions, we have used the DPPH radical scavenging assay.…”
Section: Discussionmentioning
confidence: 99%
“…Yeast α-glucosidase is available in pure form from commercial sources and has been widely used as a model for investigating antiglucosidase properties of natural products. In grape skin and pomace extracts, inhibition against yeast α-glucosidase correlated with inhibition against mammalian α-glucosidase and suppression of postprandial hyperglycemia in Streptozocininduced diabetic mice [27]. To assess the radical scavenging activity of T. domingensis fruit extracts and fractions, we have used the DPPH radical scavenging assay.…”
Section: Discussionmentioning
confidence: 99%
“…To the best of our knowledge there is to date, no report on PFH derivatives acting as inhibitor for α-Gls. Consequently in this study five different poly-hydroxy functionalized PFH (PHPFH) molecules having either aliphatic-or aromatic side-chains (C 1 -C 5 ) were synthesized and their inhibitory activity against yeast and mouse α-Gls examined. The results revealed that aromatic substitution of the synthetic compounds having significant impact on their inhibitory properties against the α-Gls.…”
Section: Research Articlementioning
confidence: 99%
“…General procedure for the synthesis of compounds C 1 -C 5 A mixture of (+)-d-glucose (0.18 g, 1 mmol), barbituric acid (0.26 g, 2 mmol), amine (1 mmol), and PTSA (0.05g, 30 mol%) in EtOH (5 mL) was stirred at 50°C for 12 h. After cooling to room temperature of the reaction mixture, the precipitated product was filtered and washed with ethanol (15 mL) to afford the pure product. …”
Section: Synthesis Of the Ligandsmentioning
confidence: 99%
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