Grape skin extract protects against programmed changes in the adult rat offspring caused by maternal high-fat diet during lactation

Resende, Ângela Castro; Emiliano, A F; Cordeiro, Viviane Silva Cristino; de, Graziele Freitas; Cavalho, Lenize Costa Reis Marins de; Oliveira, Paola Raquel Braz de; Neto, Miguel Lemos; Costa, Cristiane; Boaventura, Gilson Teles; Moura, Roberto Soares de

doi:10.1016/j.jnutbio.2013.08.003

Cited by 48 publications

(84 citation statements)

References 44 publications

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“…Different studies have shown that the administration of polyphenols to dams during prenatal and early postnatal periods can exert beneficial effects on body fat gain and different metabolic disorders, such us dyslipidaemia, insulin resistance and inflammation, on their offspring in later life [15][16][17]19]. However, in most of these studies, the metabolic programming effects of polyphenols have been observed after the administration of these compounds at high doses.…”

Section: Discussionmentioning

confidence: 99%

“…We recently demonstrated that these bioactive food compounds can reach the foetuses and placentas of pregnant rats [11]. Furthermore, recent studies have shown that polyphenols can exert metabolic programming effects on the offspring through maternal intake [12][13][14][15][16][17][18][19][20]. For example, genistein was effective in preventing body weight gain of the offspring when administered during pregnancy and lactation [12,14] but also exerted harmful effects related to anxiety, aggressive behaviours, spatial learning and reproductive development [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…In another study, male and female offspring of obese rats that received quercitin at different doses (50,100 and 200 mg kg −1 of body weight/day) during pregnancy and lactation had lower body weights, improved insulin sensitivity and lower grades of inflammation than their counterparts, although most of these effects were observed at the high doses [19]. Concerning the use of extracts rich in polyphenols, the administration of a grape skin extract rich in anthocyanins at 200 mg kg −1 of body weight/day to rats fed a high-fat diet (HFD) during lactation protected their male and female offspring against oxidative stress, hypertension, body fat gain, hypertriglyceridaemia and insulin resistance in adulthood [15,16]. Beneficial effects were also observed in the male offspring of protein-restricted gestational rats that received azuki bean polyphenols that were included in the diet at 1% during lactation.…”

Section: Introductionmentioning

confidence: 99%

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Grape seed procyanidins administered at physiological doses to rats during pregnancy and lactation promote lipid oxidation and up-regulate AMPK in the muscle of male offspring in adulthood

Crescenti

Bas

Arola‐Arnal

et al. 2015

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Grape seed procyanidins administered at physiological doses to rats during pregnancy and lactation promote lipid oxidation and up-regulate AMPK in the muscle of male offspring in adulthood

Crescenti

Bas

Arola‐Arnal

et al. 2015

The Journal of Nutritional Biochemistry

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“…Since cardiovascular phenotypes often develop after a prolonged asymptomatic phase in childhood and for the sake of brevity, we have restricted this review to data obtained from adult offspring. Here we summarize in Table 1 studies documenting cardiovascular programming related to oxidative stress [43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68]. …”

Section: Impact Of Oxidative Stress On Cardiovascular Programming mentioning

confidence: 99%

“…A number of early-life insults have been reported to cause cardiovascular programming related to oxidative stress, including undernutrition [43,48,51,54,55,61,63,64], streptozotocin (STZ)-induced diabetes [44,62], preeclampsia [45,46,47], prenatal hypoxia [49,56], maternal nicotine exposure [59,60], ethanol consumption [50], maternal inflammation [57], prenatal glucocorticoid exposure [52,53,65,67,68], and maternal high-fat intake [58,66]. Limited information is available using large animals to study oxidative stress and cardiovascular programming simultaneously [67,68].…”

Section: Impact Of Oxidative Stress On Cardiovascular Programming mentioning

confidence: 99%

Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease

Tain

Hsu

2017

IJMS

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Cardiovascular disease (CVD) presents a global health burden, despite recent advances in management. CVD can originate from early life by so-called “developmental origins of health and disease” (DOHaD). Epidemiological and experimental evidence supports that early-life insults can induce programming of later CVD. Underlying the DOHaD concept, early intervention may offset programming process to prevent the development of CVD, namely reprogramming. Oxidative stress and nutrient sensing signals have been considered to be major mechanisms of cardiovascular programming, while the interplay between these two mechanisms have not been examined in detail. This review summarizes current evidence that supports the link between oxidative stress and nutrient sensing signaling to cardiovascular programming, with an emphasis on the l-arginine–asymmetric dimethylarginine (ADMA)–nitric oxide (NO) pathway. This review provides an overview of evidence from human studies supporting fetal programming of CVD, insight from animal models of cardiovascular programming and oxidative stress, impact of the l-arginine–ADMA–NO pathway in cardiovascular programming, the crosstalk between l-arginine metabolism and nutrient sensing signals, and application of reprogramming interventions to prevent the programming of CVD. A greater understanding of the mechanisms underlying cardiovascular programming is essential to developing early reprogramming interventions to combat the globally growing epidemic of CVD.

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Gestational purple grape juice consumption does not change fetal ductus arteriosus constriction in Wistar rats

Proença¹,

Miri²,

Marinho³

et al. 2022

Birth Defects Research

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Grape juice consumption may influence the early occurrence of ductal constriction during pregnancy, since the consumption of foods rich in polyphenols can be linked to the premature constriction of the ductus arteriosus. This study aimed to evaluate the effect of purple grape juice consumption during gestation on fetal ductus arteriosus closure, prostaglandin levels, and oxidative stress markers in Wistar rats. We divided 18 pregnant rats into four groups: a control group (C), a single-dose grape juice group (SDGJ), a two-dose grape juice group (TDGJ) of 7 μl/g body weight per day, and an indomethacin group (I). Blood was collected on gestational day (GD) 0, 14, and 20. Prostaglandin levels were measured, and the livers and hearts were removed from the mothers and fetuses for oxidative stress analysis; histology of the fetal ductus arteriosus was performed. Prostaglandin levels (pg/ml) at GD 20 were (C:1462.10 ± 314.61); (SDGJ:987.66 ± 86.25); (TDGJ:1290.00 ± 221.57), and (I:584.75 ± 46.77). Fetal ductus arteriosus closure occurred only in the indomethacin group. Lipid peroxidation evaluated through thiobarbituric acid reactive substances (nmol/mg protein) in maternal livers was lower in the grape juice groups (C: 4.11 ± 0.76 nmol/mg protein), (SDGJ: 2.34 ± 0.36), (TDGJ: 1.52 ± 0.18), and (I: 4.20 ± 0.76). Sulfhydryls (nmol/mg protein) were lower in the TDGJ group (C:763.59 ± 61.38 nmol/mg protein), (SDGJ:978.88 ± 158.81), (TDGJ:385.32 ± 86.78), and (I:727.72 ± 49.12). Also, superoxide dismutase activity (USOD/mg protein) was higher in fetal hearts in this group: (C:5.29 ± 0.33), (SDGJ:4.48 ± 0.47), (TDGJ:7.35 ± 0.43), and (I:6.00 ± 0.18). We conclude that grape juice consumption in pregnancy does not induce ductus arteriosus closure in the fetus and presented potential antioxidant effects.

show abstract

Grape skin extract protects against programmed changes in the adult rat offspring caused by maternal high-fat diet during lactation

Cited by 48 publications

References 44 publications

Grape seed procyanidins administered at physiological doses to rats during pregnancy and lactation promote lipid oxidation and up-regulate AMPK in the muscle of male offspring in adulthood

Grape seed procyanidins administered at physiological doses to rats during pregnancy and lactation promote lipid oxidation and up-regulate AMPK in the muscle of male offspring in adulthood

Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease

Gestational purple grape juice consumption does not change fetal ductus arteriosus constriction in Wistar rats

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