Grapefruit consumption improves vitamin C status in periodontitis patients

Staudte, Henrike; Sigusch, Bernd W.; Glockmann, E

doi:10.1038/sj.bdj.4812613

Cited by 86 publications

(80 citation statements)

References 25 publications

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“…Vitamin C levels in the plasma of patients with periodontal disease were signifi cantly lower than those in the plasma of the healthy subjects. A similar result was observed by Staudte et al [ 78 ], who reported signifi cantly decreased plasma vitamin C levels in patients with chronic periodontitis compared with those in healthy controls. In analysis of 11,480 subjects in the Third National Health and Nutrition Examination Survey (NHANES III), Chapple et al [ 20 ] examined the association of serum antioxidant levels with an altered relative risk for periodontal disease and found a strong and consistent inverse association between serum vitamin C levels and the prevalence of periodontitis using multiple logistic regression analysis adjusted for age, sex, race/ethnicity, body mass index, cigarette smoking status, oral contraceptive and hormone replacement therapy use, diabetes, poverty income ratio, and education, with the association being stronger in patients with severe disease.…”

Section: Animal Studies On the Effects Of Vitamin C On Periodontal Disupporting

confidence: 77%

“…No relationship could be demonstrated between the presence or proportion of periodontal micro-organisms and measures of gingival bleeding or ascorbate levels. Staudte et al [ 78 ] examined plasma vitamin C levels and infl ammatory measures in patients with periodontitis before and after the consumption of grapefruit. Fifty-eight patients with chronic periodontitis were assigned to the test group ( n = 38) and a diseased control group ( n = 20) and were compared with 22 healthy subjects.…”

Section: Intervention Studies On the Effects Of Vitamin C On Periodonmentioning

confidence: 99%

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Role of Vitamin C and Vitamin E in Periodontal Disease

Nagata

2013

Studies on Periodontal Disease

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Vitamin C is a water-soluble organic substance that cannot be synthesized by the body; therefore, it must be obtained from an individual's daily diet. Also known as ascorbic acid, it is involved in wound healing and collagen production by preventing iron-dependent oxidation of lysyl and prolyl hydroxylase. In human and animal studies on vitamin C defi ciency, ascorbate supplementation increased collagen synthesis and decreased polymorphonuclear neutrophil (PMN) chemotaxis [ 4 , 5 , 9 ]. High vitamin C levels are accumulated in granulocytes, mononuclear leucocytes, and platelets [ 28 ], and neutrophil polymorphonuclear leucocytes and macrophages contain an intracellular ascorbate concentration that is 10-40 times higher than that in the plasma [ 58 ]. Chapple and Matthews [ 19 ] summarized the following functions of vitamin C: (1) scavenging water-soluble peroxyl radicals; (2) scavenging superoxide and perhydroxyl radicals; (3) preventing damage mediated by hydroxyl radicals on uric acid; (4) scavenging hypochlorous acid; (5) decreasing heme breakdown and subsequent Fe 2+ release, thereby preventing Fenton reactions; (6) scavenging single oxygen and hydroxyl radicals; (7) re-forming α-tocopherol from its radical; (8) protecting against reactive oxygen species (ROS) released from cigarette smoke; (9) reducing C-reactive protein-mediated expression of monocyte adhesion molecules; (10) decreasing pro-infl ammatory gene expression through effects on the nuclear factor-κB transcription factor.Vitamin E, which comprises related compounds named tocopherols or tocotrienols, is a fat-soluble vitamin with primary function of antioxidation. It is essential for maintaining cell membrane integrity against lipid peroxidation by peroxyl

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Section: Animal Studies On the Effects Of Vitamin C On Periodontal Disupporting

confidence: 77%

Section: Intervention Studies On the Effects Of Vitamin C On Periodonmentioning

confidence: 99%

Role of Vitamin C and Vitamin E in Periodontal Disease

Nagata

2013

Studies on Periodontal Disease

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“…Likewise, vitamin C plays a role in collagen synthesis. This is relevant for the maintenance of oral tissue such as the periodontal ligament, the formation of bone matrix, and the integrity of blood vessel walls [28]. Leggott et al [29] found that the GI values decreased after the supplementation period, suggesting that measurements of gingival inflammation are directly related to the ascorbic acid status.…”

Section: Discussionmentioning

confidence: 99%

Improvement in periodontal healing after periodontal surgery supported by nutritional supplement drinks

Lee

Park

Jung

et al. 2014

J Periodontal Implant Sci

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PurposeThe aim of this study was to determine the effects of nutritional supplements on periodontal health and tooth mobility after surgery.MethodsPatients were randomly assigned to an intervention group who consumed nutritional supplement drinks for 8 weeks, while the placebo group did not receive any such supplements. The gingival index (GI) and tooth mobility were measured at baseline and at 1, 4, and 8 weeks. In addition, the oral health impact profile-14 and anthropometric measurements along with loss of appetite and dietary intake were assessed at baseline and 8 weeks.ResultsAt 1 week, GI values were reduced in the intervention group (P<0.05), and tooth mobility had increased, but to a lesser extent in the intervention group (P<0.05). At 8 weeks, the intakes of protein, vitamins A and B1, and niacin were increased in the intervention group.ConclusionsThese results demonstrate that nutritional supplementation improves early periodontal healing after surgery.Graphical Abstract

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“…Aufnahme von Elektronen oxidative Verbindungen inaktiviert. Experimentell ist es gelungen, durch eine Erhöhung der Vitamin-C-Aufnahme die Aktivität sulkulärer Granulozyten bei Patienten mit Parodontitis zu steigern und dadurch die lokale Abwehrlage zu verbessern [20]. Außerdem spielt Vitamin C eine wesentliche Rolle in der Kollagensynthese.…”

Section: Vitamin Cunclassified

Einfluss spezieller Mikronährstoffe auf die Parodontitis

Staudte¹

2015

Stomatologie

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Grapefruit consumption improves vitamin C status in periodontitis patients

Cited by 86 publications

References 25 publications

Role of Vitamin C and Vitamin E in Periodontal Disease

Role of Vitamin C and Vitamin E in Periodontal Disease

Improvement in periodontal healing after periodontal surgery supported by nutritional supplement drinks

Einfluss spezieller Mikronährstoffe auf die Parodontitis

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