Graph analysis of cortical reorganization after virtual reality-based rehabilitation following stroke: a pilot randomized study

Abstract

IntroductionStroke is the leading cause of functional disability worldwide. With the increase of the global population, motor rehabilitation of stroke survivors is of ever-increasing importance. In the last decade, virtual reality (VR) technologies for rehabilitation have been extensively studied, to be used instead of or together with conventional treatments such as physiotherapy or occupational therapy. The aim of this work was to evaluate the GestureCollection VR-based rehabilitation tool in terms of the brain changes and clinical outcomes of the patients.MethodsTwo groups of chronic patients underwent a rehabilitation treatment with (experimental) or without (control) complementation with GestureCollection. Functional magnetic resonance imaging exams and clinical assessments were performed before and after the treatment. A functional connectivity graph-based analysis was used to assess differences between the connections and in the network parameters strength and clustering coefficient.ResultsPatients in both groups showed improvement in clinical scales, but there were more increases in functional connectivity in the experimental group than in the control group.DiscussionThe experimental group presented changes in the connections between the frontoparietal and the somatomotor networks, associative cerebellum and basal ganglia, which are regions associated with reward-based motor learning. On the other hand, the control group also had results in the somatomotor network, in its ipsilateral connections with the thalamus and with the motor cerebellum, which are regions more related to a purely mechanical activity. Thus, the use of the GestureCollection system was successfully shown to promote neuroplasticity in several motor-related areas.

Effects of Virtual Reality Cognitive Training on Neuroplasticity: A Quasi-Randomized Clinical Trial in Patients with Stroke

“…The findings revealed a significant increase in both alpha and beta bands in the experimental group following the intervention, suggesting that VRT had a positive impact on neural oscillatory activity, especially in the right hemisphere (which was the focus of the present study). The observed increase in alpha and beta bands aligns with previous research, demonstrating the neuroplasticity-inducing effects of VR-based interventions on brain activity [54][55][56][57][58][59][60][61]. The ability of VRT to engage and challenge the neural networks involved in cognitive processes may account for the observed changes in neural oscillations [62].…”

“…The ability of VRT to engage and challenge the neural networks involved in cognitive processes may account for the observed changes in neural oscillations [62]. Specifically, the increase in alpha power could indicate enhanced attentional focus and cognitive resource allocation [29,56], while the rise in beta power may reflect improved cognitive control and motor planning [63]. The control group did not exhibit significant changes in alpha and beta bands over time.…”